Quenched fluorescent peptide substrates - Tools for the discovery of novel biomarkers

被引：0
|
作者：
Lai, Zon W. [1 ]
Hanchapola, Iresha [1 ]
Smith, A. Ian [1 ]
机构：
[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia
来源：
CHIMICA OGGI-CHEMISTRY TODAY | 2008年 / 26卷 / 02期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The use of quenched fluorogenic labelled peptide substrates is growing and they have proved to be a valuable and effective tool for the rapid and sensitive screening for enzyme (particularly proteolytic) activity. Short synthetic peptides containing a quencher and the fluorophore provides high specificity and sensitivity to monitor enzyme cleavage and they thus have the potential to rapidly identify novel protease biomarkers for disease.
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页码：18 / 21
页数：4
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