Quenched fluorescent peptide substrates - Tools for the discovery of novel biomarkers

被引：0

作者：

Lai, Zon W. ^{[1
]}

Hanchapola, Iresha ^{[1
]}

Smith, A. Ian ^{[1
]}

机构：

[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

来源：

CHIMICA OGGI-CHEMISTRY TODAY | 2008年 / 26卷 / 02期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The use of quenched fluorogenic labelled peptide substrates is growing and they have proved to be a valuable and effective tool for the rapid and sensitive screening for enzyme (particularly proteolytic) activity. Short synthetic peptides containing a quencher and the fluorophore provides high specificity and sensitivity to monitor enzyme cleavage and they thus have the potential to rapidly identify novel protease biomarkers for disease.

引用

页码：18 / 21

页数：4

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