Proliferative glomerulonephritis with monoclonal immunoglobulin deposits associated with parvovirus B19

被引:6
|
作者
Santana de Roberts, Rosalba [1 ]
Batal, Ibrahim [2 ]
Aljareh, Amr [1 ]
Jim, Belinda [1 ]
机构
[1] Jacobi Med Ctr, Dept Med, Bronx, NY 10461 USA
[2] NewYork Presbyterian Hosp, Dept Pathol, New York, NY USA
关键词
nephrotic syndrome; proteinurea; immunology; drugs; infectious diseases; IGG DEPOSITS; INFECTION; PATIENT;
D O I
10.1136/bcr-2021-243061
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is included in the group of dysproteinaemias causing renal disease. Only a minority of cases are associated with a haematological malignancy. Two cases have been linked to acute parvovirus B19 infections. We report a 36-year-old African-American woman who presented with renal dysfunction, proteinuria, haematuria and a kidney biopsy reported as PGNMID with IgG3-kappa deposits. Her evaluation for a haematological malignancy was unrevealing. Her parvovirus IgM and IgG levels were positive. The patient was initially treated with an ACE inhibitor and spontaneously remitted with minimal proteinuria after 1 month. Repeat parvovirus B19 serologies 6 months later showed persistent IgG and DNA by PCR positivity but IgM negativity. Given the clinical scenario, we believe that her PGNMID was induced by acute parvovirus B19 infection, which appeared to resolve once her acute infection abated. In this report, we describe our latest understanding of PGNMID.
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页数:5
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