Depsitinuside: a new depside galactoside from an endophytic fungus isolated from Viburnum tinus

被引：2

作者：

Nazir, Mamona ^{[1
]}

Sultan, Misbah ^{[1
]}

Riaz, Naheed ^{[1
]}

Hafeez, Maria ^{[1
]}

Hussain, Hidayat ^{[2
]}

Ahmed, Ishtiaq ^{[2
]}

Schulz, Barbara ^{[3
]}

Draeger, Siegfried ^{[3
]}

Jabbar, Abdul ^{[1
]}

Krohn, Karsten ^{[2
]}

Ashraf, Muhammad ^{[4
]}

Saleem, Muhammad ^{[1
]}

机构：

[1] Islamia Univ Bahawalpur, Dept Chem, Bahawalpur 63100, Pakistan

[2] Univ Paderborn, Dept Chem, D-33098 Paderborn, Germany

[3] Tech Univ Carolo Wilhelmina Braunschweig, Inst Microbiol, D-31806 Braunschweig, Germany

[4] Islamia Univ Bahawalpur, Fac Pharm & Alternat Med, Dept Pharm, Bahawalpur 63100, Pakistan

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2011年 / 13卷 / 11期

关键词：

Viburnum tinus; endophytic fungus; depside; steroids; enzyme inhibition; SECONDARY METABOLITES; NATURAL-PRODUCTS; MICROORGANISMS; DIVERSITY;

D O I：

10.1080/10286020.2011.606811

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chromatographic purification of the extract of an endophytic fungal culture yielded depsitinuside (1), a new phenolic ester together with ergosterol (2) and (22E,24S)-24-methyl-5-alpha-cholesta-7,22-diene-3 beta,5,6 beta-triol (3).The structure of 1 was elucidated based on 1D, 2D NMR spectroscopy and high-resolution mass spectrometry, whereas the known compounds (2 and 3) were identified by 1 H NMR, mass spectrometry, and in comparison with the literature values. Compound 1 was evaluated for its enzyme inhibitory potential against acetylcholinesterase, butyrylcholinesterase and lipoxygenase, and was found inactive (10%-40% inhibition at a concentration of 2 mg/ml).

引用

页码：1056 / 1060

页数：5

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