Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library

被引：27

作者：

Sun, Dianqing ^{[1
]}

Jones, Victoria ^{[2
]}

Carson, Elizabeth I. ^{[1
]}

Lee, Robin E. B. ^{[1
]}

Scherman, Michael S. ^{[2
]}

McNeil, Michael R. ^{[2
]}

Lee, Richard E. ^{[1
]}

机构：

[1] Univ Tennessee, Ctr Hlth Sci, Dept Pharmaceut Sci, Memphis, TN 38163 USA

[2] Colorado State Univ, Dept Microbiol, Ft Collins, CO 80523 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 24期

关键词：

mureidomycins; uridine-based library; solid-phase synthesis; IRORI technology; anti-tuberculosis activity; tuberculosis; antibiotic;

D O I：

10.1016/j.bmcl.2007.09.097

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A 1000-member uridinyl branched peptide library was synthesized on PS-DES support using IRORI technology. Highthroughput screening of this library for anti -tuberculosis activity identified several members with a MIC90 value of 12.5 mu g/mL. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6899 / 6904

页数：6

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