Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library

被引：27

作者：

Sun, Dianqing ^{[1
]}

Jones, Victoria ^{[2
]}

Carson, Elizabeth I. ^{[1
]}

Lee, Robin E. B. ^{[1
]}

Scherman, Michael S. ^{[2
]}

McNeil, Michael R. ^{[2
]}

Lee, Richard E. ^{[1
]}

机构：

[1] Univ Tennessee, Ctr Hlth Sci, Dept Pharmaceut Sci, Memphis, TN 38163 USA

[2] Colorado State Univ, Dept Microbiol, Ft Collins, CO 80523 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 24期

关键词：

mureidomycins; uridine-based library; solid-phase synthesis; IRORI technology; anti-tuberculosis activity; tuberculosis; antibiotic;

D O I：

10.1016/j.bmcl.2007.09.097

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A 1000-member uridinyl branched peptide library was synthesized on PS-DES support using IRORI technology. Highthroughput screening of this library for anti -tuberculosis activity identified several members with a MIC90 value of 12.5 mu g/mL. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6899 / 6904

页数：6

共 50 条

[21] PEGA supports for combinatorial peptide synthesis and solid-phase enzymatic library assays
Renil, M
Ferreras, M
Delaisse, JM
Foged, NT
Meldal, M
JOURNAL OF PEPTIDE SCIENCE, 1998, 4 (03) : 195 - 210
[22] High Throughput Solid-Phase Peptide Synthesis with Preactivation on the Overture Robotic Peptide Library Synthesizer
Onaiyekan, M. A.
Cain, J. P.
Chantell, C. A.
Menakuru, M.
BIOPOLYMERS, 2013, 100 (03) : 319 - 319
[23] Solid-phase combinatorial synthesis of aeruginosin derivatives and their biological evaluation
Doi, Takayuki
Hoshina, Yoichiro
Mogi, Hiroyuki
Yamada, Yoshifumi
Takahashi, Takashi
JOURNAL OF COMBINATORIAL CHEMISTRY, 2006, 8 (04): : 571 - 582
[24] Convergent solid-phase peptide synthesis
Albericio, F
LloydWilliams, P
Giralt, E
SOLID-PHASE PEPTIDE SYNTHESIS, 1997, 289 : 313 - 336
[25] SOLID-PHASE PEPTIDE-SYNTHESIS
STEWART, JM
JOURNAL OF MACROMOLECULAR SCIENCE-CHEMISTRY, 1976, A 10 (1-2): : 259 - 288
[26] APPARATUS FOR SOLID-PHASE PEPTIDE SYNTHESIS
KHOSLA, MC
SMEBY, RR
BUMPUS, FM
SCIENCE, 1967, 156 (3772) : 253 - &
[27] Customizable solid-phase peptide synthesis
Albericio, F
BIOPOLYMERS, 2005, 80 (04) : 495 - 495
[28] Handles for solid-phase peptide synthesis
Songster, MF
Barany, G
SOLID-PHASE PEPTIDE SYNTHESIS, 1997, 289 : 126 - 174
[29] Bradykinin in Solid-phase Peptide Synthesis
John M. Stewart
International Journal of Peptide Research and Therapeutics, 2007, 13 : 3 - 5
[30] Bradykinin in solid-phase peptide synthesis
Stewart, John M.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2007, 13 (1-2) : 3 - 5

← 1 2 3 4 5 →