Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer

被引：92

作者：

Isomoto, H

Oka, M

Yano, Y

Kanazawa, Y

Soda, H

Terada, R

Yasutake, T

Nakayama, T

Shikuwa, S

Takeshima, F

Udono, H

Murata, I

Ohtsuka, K

Kohno, S

机构：

[1] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 8528501, Japan

[2] Nagasaki Univ, Sch Med, Dept Surg 1, Nagasaki 8528501, Japan

[3] Nagasaki Univ, Sch Med, Atom Bomb Inst, Dept Pathol, Nagasaki 8528501, Japan

[4] Natl Nagasaki Med Ctr, Dept Endoscopy, Omura, Japan

[5] Nagasaki Univ, Sch Med, Dept Immunol, Nagasaki 852, Japan

[6] Nagasaki Univ, Grad Sch Biomed Sci, Dept Pharmacotherapeut, Nagasaki, Japan

[7] Chubu Univ, Coll Biosci & Biotechnol, Lab Cell & Stress Biol, Kasugai, Aichi, Japan

来源：

CANCER LETTERS | 2003年 / 198卷 / 02期

关键词：

heat shock protein 70; heat shock protein 40; gastric cancer; immunohistochemistry; immunoblot;

D O I：

10.1016/S0304-3835(03)00305-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Heat shock proteins (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. We determined the expression of Hsp 70 and Hsp 40 in 81 gastric cancers. Immunoreactivities to Hsp 70 and Hsp 40 were detected in 67.9 and 22.2% of tumors, respectively. Immunohistochemical analysis showed enhanced Hsp 70 and Hsp 40 expression in gastric tumor tissue, relative to the surrounding normal tissue. Overexpression of Hsp 70 and Hsp 40 was also confirmed by immunoblotting. Among various clinicopathological parameters, low histopathological differentiation was associated with reduced expression of both proteins. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：219 / 228

页数：10

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