Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer

被引：92

作者：

Isomoto, H

Oka, M

Yano, Y

Kanazawa, Y

Soda, H

Terada, R

Yasutake, T

Nakayama, T

Shikuwa, S

Takeshima, F

Udono, H

Murata, I

Ohtsuka, K

Kohno, S

机构：

[1] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 8528501, Japan

[2] Nagasaki Univ, Sch Med, Dept Surg 1, Nagasaki 8528501, Japan

[3] Nagasaki Univ, Sch Med, Atom Bomb Inst, Dept Pathol, Nagasaki 8528501, Japan

[4] Natl Nagasaki Med Ctr, Dept Endoscopy, Omura, Japan

[5] Nagasaki Univ, Sch Med, Dept Immunol, Nagasaki 852, Japan

[6] Nagasaki Univ, Grad Sch Biomed Sci, Dept Pharmacotherapeut, Nagasaki, Japan

[7] Chubu Univ, Coll Biosci & Biotechnol, Lab Cell & Stress Biol, Kasugai, Aichi, Japan

来源：

CANCER LETTERS | 2003年 / 198卷 / 02期

关键词：

heat shock protein 70; heat shock protein 40; gastric cancer; immunohistochemistry; immunoblot;

D O I：

10.1016/S0304-3835(03)00305-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Heat shock proteins (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. We determined the expression of Hsp 70 and Hsp 40 in 81 gastric cancers. Immunoreactivities to Hsp 70 and Hsp 40 were detected in 67.9 and 22.2% of tumors, respectively. Immunohistochemical analysis showed enhanced Hsp 70 and Hsp 40 expression in gastric tumor tissue, relative to the surrounding normal tissue. Overexpression of Hsp 70 and Hsp 40 was also confirmed by immunoblotting. Among various clinicopathological parameters, low histopathological differentiation was associated with reduced expression of both proteins. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：219 / 228

页数：10

共 50 条

[31] Regulation of cutaneous heat shock protein 70 (HSP70) expression by p53
Trotter, MJ
Quenneville, LA
Li, HY
Zhou, X
Tron, VA
LABORATORY INVESTIGATION, 1999, 79 (01) : 64A - 64A
[32] Expression of heat shock protein 70 (HSP70) at the interface of polymer-implants in vivo
Klosterhalfen, B
Klinge, U
Tietze, L
Henze, U
Muys, L
Mittermayer, C
Bhardwaj, RS
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2000, 11 (03) : 175 - 181
[33] Circulating autoantibodies to heat shock protein (Hsp) Hsp70 and Hsp40 in sera of patients with ulcerative colitis and Crohn's disease.
Sato, S
Oka, M
Nakamura, T
Narasaki, F
Fukuda, M
Ikeda, K
Mizuta, Y
Soda, H
Ohtsuka, K
Kohno, S
GASTROENTEROLOGY, 1998, 114 (04) : A1076 - A1077
[34] Carboxy terminus of heat shock protein (HSP) 70-interacting protein (CHIP) inhibits HSP70 in the heart
Bijun Zhao
Guocheng Sun
Guanli Feng
Weixun Duan
Xiaoling Zhu
Shaoyang Chen
Lichao Hou
Zhenxiao Jin
Dinghua Yi
Journal of Physiology and Biochemistry, 2012, 68 : 485 - 491
[35] Carboxy terminus of heat shock protein (HSP) 70-interacting protein (CHIP) inhibits HSP70 in the heart
Zhao, Bijun
Sun, Guocheng
Feng, Guanli
Duan, Weixun
Zhu, Xiaoling
Chen, Shaoyang
Hou, Lichao
Jin, Zhenxiao
Yi, Dinghua
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2012, 68 (04) : 485 - 491
[36] Overexpression of the heat shock protein HSP70 family and p53 protein and prognosis for patients with gastric cancer
Maehara, Y
Oki, E
Abe, T
Tokunaga, E
Shibahara, K
Kakeji, Y
Sugimachi, K
ONCOLOGY, 2000, 58 (02) : 144 - 151
[37] Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target
Evans, Christopher G.
Chang, Lyra
Gestwicki, Jason E.
JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (12) : 4585 - 4602
[38] Immunolocalization of heat shock protein 70 (Hsp70) in boar spermatozoa
不详
REPRODUCTION IN DOMESTIC ANIMALS, 2005, 40 (04) : 377 - 377
[39] Heat shock protein (hsp60, hsp70, hsp90) expression in earthworms exposed to metal stressors in the field and laboratory
Mariño, F
Winters, C
Morgan, AJ
PEDOBIOLOGIA, 1999, 43 (06) : 615 - 624
[40] Study　of　Heat　Shock　Protein　HSP90α，HSP70，HSP27　mRNA　Expression　in　Human　Acute　Leukemia　Cells
肖侃艳
刘文励
屈伸
孙汉英
唐锦治
同济医科大学学报(外文版), 1996, (04) : 212 - 216

← 1 2 3 4 5 →