Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes

被引：9
|
作者：
Grguric-Sipka, Sanja [1 ]
Alshtewi, Mohamed Al. Arbi M. [1 ]
Jeremic, Dejan [1 ]
Kaluderovic, Goran N. [2 ]
Gomez-Ruiz, Santiago [3 ]
Zizak, Zeljko [4 ]
Juranic, Zorica [4 ]
Sabo, Tibor J. [1 ]
机构：
[1] Univ Belgrade, Fac Chem, Belgrade 11000, Serbia
[2] Inst Chem Technol & Met, Dept Chem, Belgrade 11000, Serbia
[3] Univ Rey Juan Carlos, ESCET, Dept Quim Inorgan & Analit, Madrid 28933, Spain
[4] Inst Oncol & Radiol, Belgrade, Serbia
来源：
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2008年 / 73卷 / 06期
关键词：
ruthenium(II) complexes; p-cymene; K-3-thiosemicarbazone; N-methylpiperazine; cytotoxic activity;
D O I：
10.2298/JSC0806619G
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(eta(6)-p-cymene)RuCl2(CH3NH(CH2)(4)NH)]PF6, complex 1) or vitamin K-3-thiosemicarbazone ([(eta(6)-p-cymene)RuCl2(K(3)tsc)], complex 2) were synthesized starting from [(eta(6)-p-cymene)(2)RuCl2](2) and the corresponding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure determination of complex 1 revealed "piano-stool" geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand present.
引用
收藏
页码：619 / 630
页数：12
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