Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes

被引：9
|
作者：
Grguric-Sipka, Sanja [1 ]
Alshtewi, Mohamed Al. Arbi M. [1 ]
Jeremic, Dejan [1 ]
Kaluderovic, Goran N. [2 ]
Gomez-Ruiz, Santiago [3 ]
Zizak, Zeljko [4 ]
Juranic, Zorica [4 ]
Sabo, Tibor J. [1 ]
机构：
[1] Univ Belgrade, Fac Chem, Belgrade 11000, Serbia
[2] Inst Chem Technol & Met, Dept Chem, Belgrade 11000, Serbia
[3] Univ Rey Juan Carlos, ESCET, Dept Quim Inorgan & Analit, Madrid 28933, Spain
[4] Inst Oncol & Radiol, Belgrade, Serbia
来源：
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2008年 / 73卷 / 06期
关键词：
ruthenium(II) complexes; p-cymene; K-3-thiosemicarbazone; N-methylpiperazine; cytotoxic activity;
D O I：
10.2298/JSC0806619G
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(eta(6)-p-cymene)RuCl2(CH3NH(CH2)(4)NH)]PF6, complex 1) or vitamin K-3-thiosemicarbazone ([(eta(6)-p-cymene)RuCl2(K(3)tsc)], complex 2) were synthesized starting from [(eta(6)-p-cymene)(2)RuCl2](2) and the corresponding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure determination of complex 1 revealed "piano-stool" geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand present.
引用
收藏
页码：619 / 630
页数：12
相关论文
共 50 条
  • [11] Titanium(IV) carboxylate complexes: Synthesis, structural characterization and cytotoxic activity
    Gomez-Ruiz, Santiago
    Gallego, Beatriz
    Zizak, Zeljko
    Hey-Hawkins, Evamarie
    Juranic, Zorica D.
    Kaluderovic, Goran N.
    POLYHEDRON, 2010, 29 (01) : 354 - 360
  • [12] Synthesis, characterization, antitumor, and cytotoxic activity of mononuclear Ru(II) complexes
    Thota, Sreekanth
    Karki, Subhas Somalingappa
    Jayaveera, K. N.
    Balzarini, Jan
    De Clercq, Erik
    JOURNAL OF COORDINATION CHEMISTRY, 2010, 63 (24) : 4332 - 4346
  • [13] Synthesis, characterization and cytotoxic activity of palladium (II) dithiocarbamate complexes with α,ω-diamines
    Montagner, Diego
    Marzano, Cristina
    Gandin, Valentina
    INORGANICA CHIMICA ACTA, 2011, 376 (01) : 574 - 580
  • [14] Synthesis, characterization and cytotoxic activity of novel platinum(II) iodido complexes
    Savic, Aleksandar
    Filipovic, Lana
    Arandelovic, Sandra
    Dojcinovic, Biljana
    Radulovic, Sinisa
    Sabo, Tibor J.
    Grguric-Sipka, Sanja
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 82 : 372 - 384
  • [15] Synthesis, characterisation and cytotoxic activity of organoruthenium(II)-halido complexes with 1H-benzimidazole-2-carboxylic acid
    Pantic, Darko N.
    Arandelovic, Sandra
    Radulovic, Sinisa
    Roller, Alexander
    Arion, Vladimir B.
    Grguric-Sipka, Sanja
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2016, 819 : 61 - 68
  • [16] Synthesis, structural characterization, and cytotoxic activity of new spirocyclic octachlorocyclotetraphosphazenes
    Isiklan, Muhammet
    Sayin, Levent
    Sonkaya, Omer
    Hokelek, Tuncer
    Turk, Mustafa
    Oguztuzun, Serpil
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2016, 191 (09) : 1216 - 1222
  • [17] Zn(II) complexes with a new isoniazid ligand: synthesis, structural characterization and antimycobacterial activity
    Santiago, Pedro H. O.
    Bessa, Meliza A. S.
    Menezes, Ralciane P.
    Martins, Carlos H. G.
    Gatto, Claudia C.
    JOURNAL OF COORDINATION CHEMISTRY, 2022, 75 (3-4) : 347 - 361
  • [18] Mono- and polynuclear complexes Synthesis, spectroscopic and of Pt(II) with polypyridyl ligands structural characterization and cytotoxic activity
    Rubino, S.
    Portanova, P.
    Albanese, A.
    Calvaruso, G.
    Orecchio, S.
    Fontana, G.
    Stocco, G. C.
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2007, 101 (10) : 1473 - 1482
  • [19] Selective, Cytotoxic Organoruthenium(II) Full-Sandwich Complexes: A Structural, Computational and In Vitro Biological Study
    Loughrey, Bradley T.
    Cunning, Benjamin V.
    Healy, Peter C.
    Brown, Christopher L.
    Parsons, Peter G.
    Williams, Michael L.
    CHEMISTRY-AN ASIAN JOURNAL, 2012, 7 (01) : 112 - 121
  • [20] Ruthenium(II)-arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity
    Grguric-Sipka, Sanja
    Ivanovic, Ivanka
    Rakic, Gordana
    Todorovic, Nina
    Gligorijevic, Nevenka
    Radulovic, Sinisa
    Arion, Vladimir B.
    Keppler, Bernhard K.
    Tesic, Zivoslav Lj.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (03) : 1051 - 1058
12345