Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes

被引：9

作者：

Grguric-Sipka, Sanja ^{[1
]}

Alshtewi, Mohamed Al. Arbi M. ^{[1
]}

Jeremic, Dejan ^{[1
]}

Kaluderovic, Goran N. ^{[2
]}

Gomez-Ruiz, Santiago ^{[3
]}

Zizak, Zeljko ^{[4
]}

Juranic, Zorica ^{[4
]}

Sabo, Tibor J. ^{[1
]}

机构：

[1] Univ Belgrade, Fac Chem, Belgrade 11000, Serbia

[2] Inst Chem Technol & Met, Dept Chem, Belgrade 11000, Serbia

[3] Univ Rey Juan Carlos, ESCET, Dept Quim Inorgan & Analit, Madrid 28933, Spain

[4] Inst Oncol & Radiol, Belgrade, Serbia

来源：

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2008年 / 73卷 / 06期

关键词：

ruthenium(II) complexes; p-cymene; K-3-thiosemicarbazone; N-methylpiperazine; cytotoxic activity;

D O I：

10.2298/JSC0806619G

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(eta(6)-p-cymene)RuCl2(CH3NH(CH2)(4)NH)]PF6, complex 1) or vitamin K-3-thiosemicarbazone ([(eta(6)-p-cymene)RuCl2(K(3)tsc)], complex 2) were synthesized starting from [(eta(6)-p-cymene)(2)RuCl2](2) and the corresponding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure determination of complex 1 revealed "piano-stool" geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand present.

引用

页码：619 / 630

页数：12

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