Voriconazole: review of a broad spectrum triazole antifungal agent

被引：29

作者：

Kofla, G ^{[1
]}

Ruhnke, M ^{[1
]}

机构：

[1] Humboldt Univ, Dept Med 2, Div Hematol Oncol, Charite, Berlin, Germany

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2005年 / 6卷 / 07期

关键词：

antifungal agent; azole; mould; mycoses; treatment; voriconazole;

D O I：

10.1517/14656566.6.7.1215

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Voriconazole is a second-generation triazole antifungal agent, structurally derived from fluconazole with an extended spectrum of activity against a wide variety of yeasts and moulds. Developed for the treatment of life-threatening fungal infections, it appears to be an effective therapy option for invasive aspergillosis, fluconazole-resistant candidiasis and refractory or less-common invasive fungal infections. It is available for both oral and intravenous administration and is characterised by an acceptable safety and tolerability spectrum.

引用

页码：1215 / 1229

页数：15

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