Voriconazole: review of a broad spectrum triazole antifungal agent

被引：29
|
作者：
Kofla, G [1 ]
Ruhnke, M [1 ]
机构：
[1] Humboldt Univ, Dept Med 2, Div Hematol Oncol, Charite, Berlin, Germany
来源：
EXPERT OPINION ON PHARMACOTHERAPY | 2005年 / 6卷 / 07期
关键词：
antifungal agent; azole; mould; mycoses; treatment; voriconazole;
D O I：
10.1517/14656566.6.7.1215
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Voriconazole is a second-generation triazole antifungal agent, structurally derived from fluconazole with an extended spectrum of activity against a wide variety of yeasts and moulds. Developed for the treatment of life-threatening fungal infections, it appears to be an effective therapy option for invasive aspergillosis, fluconazole-resistant candidiasis and refractory or less-common invasive fungal infections. It is available for both oral and intravenous administration and is characterised by an acceptable safety and tolerability spectrum.
引用
收藏
页码：1215 / 1229
页数：15
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