Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement

被引：37
|
作者：
Leban, J
Saeb, W
Garcia, G
Baumgartner, R
Kramer, B
机构：
[1] 4SC AG, 82152 Martinsried
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 01期
关键词：
D O I：
10.1016/j.bmcl.2003.10.021
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel series of DHODH inhibitors was developed based on a lead which was obtained by a docking procedure and a medicinal chemistry exploration. The activity of the initial lead was improved by a QSAR method to yield low nanomolar inhibitors. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：55 / 58
页数：4
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