Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement

被引：37

作者：

Leban, J

Saeb, W

Garcia, G

Baumgartner, R

Kramer, B

机构：

[1] 4SC AG, 82152 Martinsried

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 01期

关键词：

D O I：

10.1016/j.bmcl.2003.10.021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of DHODH inhibitors was developed based on a lead which was obtained by a docking procedure and a medicinal chemistry exploration. The activity of the initial lead was improved by a QSAR method to yield low nanomolar inhibitors. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：55 / 58

页数：4

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