Iron-Catalyzed Carbonylation-Peroxidation of Alkenes with Aldehydes and Hydroperoxides

被引：288
|
作者：
Liu, Weiping [1 ]
Li, Yuanming [1 ]
Liu, Kaisheng [1 ]
Li, Zhiping [1 ]
机构：
[1] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 28期
基金：
美国国家科学基金会;
关键词：
C-C BOND; RADICAL CHEMISTRY; EPOXIDATION; OXIDATION; CARBON; FUNCTIONALIZATION; HYDROACYLATION; ACTIVATION; ESTERS; SCOPE;
D O I：
10.1021/ja204226n
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A three-component reaction of alkenes, aldehydes, and hydroperoxides catalyzed by FeCl2 to beta-peroxy ketones has been achieved. This three-component reaction can be also applied to the synthesis of a-carbonyl epoxides, through either a stepwise base-induced epoxidation of the separated beta-peroxy ketone products or a one-pot process by simply adding base to the reaction mixture after the completion of the three-component reaction.
引用
收藏
页码：10756 / 10759
页数：4
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