Palladium-Catalyzed Decarboxylative Three-Component Synthesis of α-Arylglycines: Replacing Boronic with Carboxylic Acids in the Petasis Reaction

被引：10
|
作者：
Diehl, Andreas M. [1 ]
Manolikakes, Georg [1 ]
机构：
[1] Tech Univ Kaiserslautern, Dept Chem, Erwin Schrodinger Str Geb 54, D-67663 Kaiserslautern, Germany
来源：
CHEMCATCHEM | 2020年 / 12卷 / 13期
关键词：
Synthetic methods; Multicomponent reaction; Sulfonamide; Palladium; Amino acid; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; MANNICH REACTION; PALLADATION;
D O I：
10.1002/cctc.202000652
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A palladium-catalyzed three-component synthesis of alpha-arylglycines from benzoic acids, sulfonamides and glyoxylic acid is reported. This novel reaction offers straightforward access to the important arylglycine motif in good yields and high structural diversity. By replacing boronic with carboxylic acids as nucleophilic component, this method can be considered as a more sustainable version of the classical Petasis reaction for synthesis of arylglycines.
引用
收藏
页码：3463 / 3466
页数：4
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