Synthesis and biology of new thyrotropin-releasing hormone (TRH) analogues

被引：28
|
作者：
Jain, R
Singh, J
Perlman, JH
Gershengorn, MC
机构：
[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, SAS Nagar 160062, Punjab, India
[2] Cornell Univ, Weill Med Coll, Dept Med, Div Mol Med, New York, NY 10021 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 01期
关键词：
D O I：
10.1016/S0968-0896(01)00265-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：189 / 194
页数：6
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