Synthesis and biology of new thyrotropin-releasing hormone (TRH) analogues

被引：28
|
作者：
Jain, R
Singh, J
Perlman, JH
Gershengorn, MC
机构：
[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, SAS Nagar 160062, Punjab, India
[2] Cornell Univ, Weill Med Coll, Dept Med, Div Mol Med, New York, NY 10021 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 01期
关键词：
D O I：
10.1016/S0968-0896(01)00265-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：189 / 194
页数：6
相关论文
共 50 条
  • [21] Metabolism of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, by intestinal microorganisms
    Sasaki, I
    Tamura, T
    Shibakawa, T
    Fujita, T
    Murakami, M
    Yamamoto, A
    Muranishi, S
    PHARMACEUTICAL RESEARCH, 1997, 14 (08) : 1004 - 1007
  • [22] Metaanalisis, of thyrotropin-releasing hormone (TRH) associated with prenatal corticosteroids
    Salinas, R
    Pereyra, JT
    Gonzáles, LH
    PEDIATRIC RESEARCH, 2000, 47 (03) : 423 - 423
  • [23] The thyrotropin-releasing hormone (TRH)-immune system homeostatic hypothesis
    Kamath, J.
    Yarbrough, G. G.
    Prange, A. J., Jr.
    Winokur, A.
    PHARMACOLOGY & THERAPEUTICS, 2009, 121 (01) : 20 - 28
  • [24] Thyrotropin-releasing hormone (TRH): Intranasal delivery to seizure foci
    Kubek, Michael J.
    Kubek, D. J.
    Domb, A. J.
    Veronesi, M. C.
    EPILEPSIA, 2007, 48 : 310 - 311
  • [25] The role of the thyrotropin-releasing hormone (TRH) neuron as a metabolic sensor
    Hollenberg, Anthony N.
    THYROID, 2008, 18 (02) : 131 - 139
  • [26] STUDIES ON THYROTROPIN-RELEASING HORMONE (TRH) ACTIVITY IN PERIPHERAL BLOOD
    REDDING, TW
    SCHALLY, AV
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1969, 131 (02): : 420 - &
  • [27] THYROTROPIN-RELEASING HORMONE (TRH) STUDIES IN PATIENTS WITH THYROID CANCER
    SAMAAN, NA
    BECEIRO, JR
    HAYNIE, TP
    HILL, CS
    GLENN, HJ
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1972, 35 (03): : 438 - +
  • [28] ADRENERGIC MANIPULATION AND THYROTROPIN-RELEASING HORMONE (TRH)-INDUCED THYROTROPIN (TSH) RELEASE
    WOOLF, PD
    SCHALCH, DS
    LEE, LA
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1972, 35 (04): : 616 - +
  • [29] Thyrotropin-releasing hormone (TRH) is a novel is a novel pigmentary hormone in situ and in vitro
    Nguyen-Thi, K. T.
    Gaspar, E.
    Hardenbicker, C.
    Pattwell, D.
    Tiede, S.
    Paus, R.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 : S147 - S147
  • [30] Molecular and cellular biology of thyrotropin-releasing hormone receptors
    Gershengorn, MC
    Osman, R
    PHYSIOLOGICAL REVIEWS, 1996, 76 (01) : 175 - 191
12345