Genetics of atopic dermatitis

被引：30

作者：

Bussmann, Caroline ^{[1
]}

Weidinger, Stephan ^{[2
]}

Novak, Natalija ^{[1
]}

机构：

[1] Univ Bonn, Dept Dermatol & Allergy, D-53127 Bonn, Germany

[2] Tech Univ Munich, Dept Dermatol & Allergy, D-8000 Munich, Germany

来源：

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT | 2011年 / 9卷 / 09期

关键词：

atopic dermatitis; genetics; filaggrin; epidermal barrier; polymorphisms; OF-FUNCTION MUTATIONS; POPULATION-BASED COHORT; SERUM IGE LEVELS; FILAGGRIN MUTATIONS; PROMOTER POLYMORPHISM; CHILDHOOD ECZEMA; BARRIER FUNCTION; GERMAN PATIENTS; ASSOCIATION; RISK;

D O I：

10.1111/j.1610-0387.2011.07656.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Atopic dermatitis (AD) is a multifactorial disease, with a strong genetic predisposition. Genome-wide studies as well as candidate gene studies revealed several susceptibility loci. Since the observation of a strong association of "loss of function" mutations in the filaggrin gene with AD, the epidermal barrier was rediscovered as important pathophysiological co-factor of this disease.

引用

页码：670 / 676

页数：7

共 50 条

[31] The genetic architecture and population genetics of filaggrin-related atopic dermatitis
O'Regan, G. M.
Irvine, A. D.
Chen, H.
Nomura, T.
Campbell, L. E.
Zhao, Y.
Liao, H.
Palmer, C. N.
Smith, F. J.
McLean, W.
Sandilands, A.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2008, 128 : S128 - S128
[32] Overlapping Features of Psoriasis and Atopic Dermatitis: From Genetics to Immunopathogenesis to Phenotypes
Tsai, Ya-Chu
Tsai, Tsen-Fang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (10)
[33] The genetics of atopic dermatitis: Strategies, candidate genes, and genome screens - Discussion
Gleich
Cookson, WOCM
Ring, J
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2001, 45 (01) : S9 - S9
[34] Peeling off the genetics of atopic dermatitis-like congenital disorders
Samuelov, Liat
Sprecher, Eli
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 134 (04) : 808 - 815
[35] The mannose-binding lectin gene in atopic dermatitis: lessons from genetics
Shakir, Ebrahim M.
Grayson, Mitchell H.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2010, 105 (01) : 1 - 2
[36] How atopic is atopic dermatitis?
Flohr, C
Johansson, SGO
Wahlgren, CF
Williams, H
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 114 (01) : 150 - 158
[37] Atopic dermatitis or atopic eczema?
Gjersvik, Petter
Langeland, Tor
TIDSSKRIFT FOR DEN NORSKE LAEGEFORENING, 2021, 141 (08) : 780 - 780
[38] Atopic keratoconjunctivitis and atopic dermatitis
Guglielmetti, Stefano
Dart, John K. G.
Calder, Virginia
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 10 (05) : 478 - 485
[39] Atopic Dermatitis
Lange, D.
ALLERGOLOGIE, 2013, 36 (04) : 193 - 194
[40] Atopic dermatitis
Peters, Neill
Peters, Anju T.
ALLERGY AND ASTHMA PROCEEDINGS, 2019, 40 (06) : 433 - 436

← 1 2 3 4 5 →