Genetics of atopic dermatitis

被引：30

作者：

Bussmann, Caroline ^{[1
]}

Weidinger, Stephan ^{[2
]}

Novak, Natalija ^{[1
]}

机构：

[1] Univ Bonn, Dept Dermatol & Allergy, D-53127 Bonn, Germany

[2] Tech Univ Munich, Dept Dermatol & Allergy, D-8000 Munich, Germany

来源：

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT | 2011年 / 9卷 / 09期

关键词：

atopic dermatitis; genetics; filaggrin; epidermal barrier; polymorphisms; OF-FUNCTION MUTATIONS; POPULATION-BASED COHORT; SERUM IGE LEVELS; FILAGGRIN MUTATIONS; PROMOTER POLYMORPHISM; CHILDHOOD ECZEMA; BARRIER FUNCTION; GERMAN PATIENTS; ASSOCIATION; RISK;

D O I：

10.1111/j.1610-0387.2011.07656.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Atopic dermatitis (AD) is a multifactorial disease, with a strong genetic predisposition. Genome-wide studies as well as candidate gene studies revealed several susceptibility loci. Since the observation of a strong association of "loss of function" mutations in the filaggrin gene with AD, the epidermal barrier was rediscovered as important pathophysiological co-factor of this disease.

引用

页码：670 / 676

页数：7

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