Genetics of atopic dermatitis

被引：30
|
作者：
Bussmann, Caroline [1 ]
Weidinger, Stephan [2 ]
Novak, Natalija [1 ]
机构：
[1] Univ Bonn, Dept Dermatol & Allergy, D-53127 Bonn, Germany
[2] Tech Univ Munich, Dept Dermatol & Allergy, D-8000 Munich, Germany
来源：
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT | 2011年 / 9卷 / 09期
关键词：
atopic dermatitis; genetics; filaggrin; epidermal barrier; polymorphisms; OF-FUNCTION MUTATIONS; POPULATION-BASED COHORT; SERUM IGE LEVELS; FILAGGRIN MUTATIONS; PROMOTER POLYMORPHISM; CHILDHOOD ECZEMA; BARRIER FUNCTION; GERMAN PATIENTS; ASSOCIATION; RISK;
D O I：
10.1111/j.1610-0387.2011.07656.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Atopic dermatitis (AD) is a multifactorial disease, with a strong genetic predisposition. Genome-wide studies as well as candidate gene studies revealed several susceptibility loci. Since the observation of a strong association of "loss of function" mutations in the filaggrin gene with AD, the epidermal barrier was rediscovered as important pathophysiological co-factor of this disease.
引用
收藏
页码：670 / 676
页数：7
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