NSD1 is essential for early post-implantation development and has a catalytically active SET domain

被引：275
|
作者：
Rayasam, GV
Wendling, O
Angrand, PO
Mark, M
Niederreither, K
Song, L
Lerouge, T
Hager, GL
Chambon, P
Losson, R
机构：
[1] NIH, Lab Receptor Biol & Gene Express, Bethesda, MD 20892 USA
[2] Baylor Coll Med, Dept Med, Ctr Cardiovasc Dev, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Mol & Cellular Biol, Ctr Cardiovasc Dev, Houston, TX 77030 USA
[4] Coll France, ULP, INSERM, CNRS,Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France
[5] Cellzome AG, D-69117 Heidelberg, Germany
来源：
EMBO JOURNAL | 2003年 / 22卷 / 12期
关键词：
gastrulation; gene disruption; HMTase; nuclear receptor cofactor; SET domain;
D O I：
10.1093/emboj/cdg288
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The nuclear receptor-binding SET domain-containing protein (NSD1) belongs to an emerging family of proteins, which have all been implicated in human malignancy. To gain insight into the biological functions of NSD1, we have generated NSD1-deficient mice by gene disruption. Homozygous mutant NSD1 embryos, which initiate mesoderm formation, display a high incidence of apoptosis and fail to complete gastrulation, indicating that NSD1 is a developmental regulatory protein that exerts function(s) essential for early post-implantation development. We have also examined the enzymatic potential of NSD1 and found that its SET domain possesses intrinsic histone methyltransferase activity with specificity for Lys36 of histone H3 (M-K36) and Lys20 of histone H4 (H4K20).
引用
收藏
页码：3153 / 3163
页数：11
相关论文
共 50 条
  • [41] Elg1 (Enhanced level of genome instability 1) has an essential role in early development and suppressing tumorigenesis
    Sikdar, Nilabja
    Myung, Kyungjae
    FASEB JOURNAL, 2010, 24
  • [42] Three-dimensional microCT imaging of murine embryonic development from immediate post-implantation to organogenesis: application for phenotyping analysis of early embryonic lethality in mutant animals
    Olga Ermakova
    Tiziana Orsini
    Alessia Gambadoro
    Francesco Chiani
    Glauco P. Tocchini-Valentini
    Mammalian Genome, 2018, 29 : 245 - 259
  • [43] ROLE OF THE POLAR TROPHECTODERM IN DETERMINING THE PATTERN OF EARLY POST-IMPLANTATION MORPHOGENESIS IN MAMMALS - EVIDENCE FROM DEVELOPMENT OF THE SHORT-TAILED FIELD VOLE, MICROTUS-AGRESTIS
    COPP, AJ
    CLARKE, JR
    PLACENTA, 1988, 9 (06) : 643 - 653
  • [44] Three-dimensional microCT imaging of murine embryonic development from immediate post-implantation to organogenesis: application for phenotyping analysis of early embryonic lethality in mutant animals
    Ermakova, Olga
    Orsini, Tiziana
    Gambadoro, Alessia
    Chiani, Francesco
    Tocchini-Valentini, Glauco P.
    MAMMALIAN GENOME, 2018, 29 (3-4) : 245 - 259
  • [45] Trp-Asp (WD) Repeat Domain 1 Is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation
    Xiao, Yi
    Ma, Haixia
    Wan, Ping
    Qin, Dandan
    Wang, Xiaoxiao
    Zhang, Xiaoxin
    Xiang, Yunlong
    Liu, Wenbo
    Chen, Jiong
    Yi, Zhaohong
    Li, Lei
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (04) : 1438 - 1448
  • [46] Effect of super-stimulation with pregnant mare's serum gonadotropin (PMSG) on hamster 1-cell embryo pre- and post-implantation development.
    McKiernan, SH
    Bavister, BD
    BIOLOGY OF REPRODUCTION, 1996, 54 : 454 - 454
  • [47] Decreased serum dependence in the growth of NIH3T3 cells from the overexpression of human nuclear receptor-binding SET-domain-containing protein 1 (NSD1) or fission yeast su(var)3-9, enhancer-of-zeste, trithorax 2 (SET2)
    Yamada-Okabe, Toshiko
    Matsumoto, Naomichi
    CELL BIOCHEMISTRY AND FUNCTION, 2008, 26 (02) : 146 - 150
  • [48] Contrasting effects of G1.2/G2.2 and SOF1/SOF2 embryo culture media on pre- and post-implantation development of non-transgenic and transgenic cloned goat embryos
    Hosseini, Sayed Morteza
    Hajian, Mehdi
    Ostadhosseini, Somayyeh
    Forouzanfar, Mohsen
    Abedi, Parvaneh
    Jafarpour, Farnoosh
    Gourabi, Hamid
    Shahverdi, Abdol Hossein
    Vosough, Ahmad
    Ghanaie, Hamid Reza
    Nasr-Esfahani, Mohammad Hossein
    REPRODUCTIVE BIOMEDICINE ONLINE, 2015, 31 (03) : 372 - 383
  • [49] The POZ/BTB Domain Transcription Factor Miz-1 (Zbtb17) Is Required during Early B Cell Development for the Survival of B-Cell Progenitors and Is Essential for the Formation of Mature Follicular B Cells
    Kosan, Christian
    Moroy, Tarik
    BLOOD, 2008, 112 (11) : 262 - 262
  • [50] WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma
    Stec, I
    Wright, TJ
    van Ommen, GJB
    de Boer, PAJ
    van Haeringen, A
    Moorman, AFM
    Altherr, MR
    den Dunnen, JT
    HUMAN MOLECULAR GENETICS, 1998, 7 (07) : 1071 - 1082
12345