NSD1 is essential for early post-implantation development and has a catalytically active SET domain

被引：275
|
作者：
Rayasam, GV
Wendling, O
Angrand, PO
Mark, M
Niederreither, K
Song, L
Lerouge, T
Hager, GL
Chambon, P
Losson, R
机构：
[1] NIH, Lab Receptor Biol & Gene Express, Bethesda, MD 20892 USA
[2] Baylor Coll Med, Dept Med, Ctr Cardiovasc Dev, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Mol & Cellular Biol, Ctr Cardiovasc Dev, Houston, TX 77030 USA
[4] Coll France, ULP, INSERM, CNRS,Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France
[5] Cellzome AG, D-69117 Heidelberg, Germany
来源：
EMBO JOURNAL | 2003年 / 22卷 / 12期
关键词：
gastrulation; gene disruption; HMTase; nuclear receptor cofactor; SET domain;
D O I：
10.1093/emboj/cdg288
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The nuclear receptor-binding SET domain-containing protein (NSD1) belongs to an emerging family of proteins, which have all been implicated in human malignancy. To gain insight into the biological functions of NSD1, we have generated NSD1-deficient mice by gene disruption. Homozygous mutant NSD1 embryos, which initiate mesoderm formation, display a high incidence of apoptosis and fail to complete gastrulation, indicating that NSD1 is a developmental regulatory protein that exerts function(s) essential for early post-implantation development. We have also examined the enzymatic potential of NSD1 and found that its SET domain possesses intrinsic histone methyltransferase activity with specificity for Lys36 of histone H3 (M-K36) and Lys20 of histone H4 (H4K20).
引用
收藏
页码：3153 / 3163
页数：11
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