Synthesis of Sildenafil Citrate and Process Related Impurities

被引：1
|
作者：
Kumar, Indukuri V. S. [1 ]
Ramanjaneyulu, Gorantla S. [1 ]
Bindu, Vurimindi H. [2 ]
机构：
[1] Aptuit Laurus Private Ltd, Ctr Res & Dev, Hyderabad 500078, Andhra Pradesh, India
[2] JNTU, Inst Sci & Technol, Hyderabad 500072, Andhra Pradesh, India
来源：
LETTERS IN ORGANIC CHEMISTRY | 2011年 / 8卷 / 09期
关键词：
Decarboxilative etherification; sildenafil citrate; process impurities; PALLADIUM-CATALYZED DECARBOXYLATION; INTERMOLECULAR ALLYLIC ETHERIFICATION; ARYL CARBONATES; PROTECTION; PHENOLS; ETHERS;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis of Sildenafil by the O-alkylation of 5-[2-hydroxy-5-(4-methylpiperazin-1-ylsulphonyl)phenyl]-1-methyl- 3-n-propyl-1,6-dihydro-7H-pyrazolo-[4,3-d]pyrimidin-7-one 8 proved difficult because concomitant alkylation of the pyrimidine moity also occurred. The selective O-alkylation was carried by DCC assisted decarboxilative etherification of the carbonate 9.
引用
收藏
页码：668 / 673
页数：6
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