Synthesis of Sildenafil Citrate and Process Related Impurities

被引:1
|
作者
Kumar, Indukuri V. S. [1 ]
Ramanjaneyulu, Gorantla S. [1 ]
Bindu, Vurimindi H. [2 ]
机构
[1] Aptuit Laurus Private Ltd, Ctr Res & Dev, Hyderabad 500078, Andhra Pradesh, India
[2] JNTU, Inst Sci & Technol, Hyderabad 500072, Andhra Pradesh, India
关键词
Decarboxilative etherification; sildenafil citrate; process impurities; PALLADIUM-CATALYZED DECARBOXYLATION; INTERMOLECULAR ALLYLIC ETHERIFICATION; ARYL CARBONATES; PROTECTION; PHENOLS; ETHERS;
D O I
暂无
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Synthesis of Sildenafil by the O-alkylation of 5-[2-hydroxy-5-(4-methylpiperazin-1-ylsulphonyl)phenyl]-1-methyl- 3-n-propyl-1,6-dihydro-7H-pyrazolo-[4,3-d]pyrimidin-7-one 8 proved difficult because concomitant alkylation of the pyrimidine moity also occurred. The selective O-alkylation was carried by DCC assisted decarboxilative etherification of the carbonate 9.
引用
收藏
页码:668 / 673
页数:6
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