The DNA-dependent protein kinase: A matter of life and (cell) death

被引：26
|
作者：
McConnell, K
Dynan, WS
机构：
[1] Medical College of Georgia, Inst. for Molec. Med. and Genetics, Augusta, GA 30912-3175
来源：
CURRENT OPINION IN CELL BIOLOGY | 1996年 / 8卷 / 03期
关键词：
D O I：
10.1016/S0955-0674(96)80005-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The catalytic subunit of the DNA-dependent protein kinase (DNA-PK) is a member of the phosphatidylinositol 3-kinase family. Recent genetic and biochemical studies indicate the involvement of DNA-PK in immunoglobulin/T-celI-receptor gene recombination, double-strand DNA break repair, the stress response and autoimmunity. A role in the suppression of apoptosis could link some of the enzyme's diverse functions.
引用
收藏
页码：325 / 330
页数：6
相关论文
共 50 条
  • [31] Expression of DNA-dependent protein kinase in human granulocytes
    Annahita SALLMYR
    Anna MILLER
    Aida GABDOULKHAKOVA
    Valentina SAFRONOVA
    Gunnel HENRIKSSON
    Anders BREDBERG
    Cell Research, 2004, (04) : 331 - 340
  • [32] Differential role of hydrogen peroxide and staurosporine in induction of cell death in glioblastoma cells lacking DNA-dependent protein kinase
    Chen, GG
    Sin, FLF
    Leung, BCS
    Ng, HK
    Poon, WS
    APOPTOSIS, 2005, 10 (01) : 185 - 192
  • [33] Differential role of hydrogen peroxide and staurosporine in induction of cell death in glioblastoma cells lacking DNA-dependent protein kinase
    G. G. Chen
    F. L. F. Sin
    B. C. S. Leung
    H. K. Ng
    W. S. Poon
    Apoptosis, 2005, 10 : 185 - 192
  • [34] Differences in cell death of DNA-dependent protein kinase defected glioblastoma cells upon stimulation by staurosporine and hydrogen peroxide
    Chen, George G.
    Leung, Billy C. S.
    Chun, Suk Y.
    Poon, Wai S.
    ANNALS OF NEUROLOGY, 2006, 60 : S63 - S63
  • [35] DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
    Hammarsten, O
    Chu, G
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (02) : 525 - 530
  • [36] Structure of DNA-dependent protein kinase: implications for its regulation by DNA
    Leuther, KK
    Hammarsten, O
    Kornberg, RD
    Chu, G
    EMBO JOURNAL, 1999, 18 (05): : 1114 - 1123
  • [37] Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase
    Yannone, SM
    Roy, S
    Chan, DW
    Murphy, MB
    Huang, SR
    Campisi, J
    Chen, DJ
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (41) : 38242 - 38248
  • [38] DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy
    Puustinen, Pietri
    Keldsbo, Anne
    Corcelle-Termeau, Elisabeth
    Ngoei, Kevin
    Sonder, Stine L.
    Farkas, Thomas
    Kaae Andersen, Klaus
    Oakhill, Jon S.
    Jaattela, Marja
    AUTOPHAGY, 2020, 16 (10) : 1871 - 1888
  • [39] Activation mechanism of protein kinase B by DNA-dependent protein kinase involved in the DNA repair system
    Li Y.
    Piao L.
    Yang K.-J.
    Shin S.
    Shin E.
    Park K.
    Byun H.S.
    Won M.
    Choi B.L.
    Lee H.
    Kim Y.-R.
    Hong J.H.
    Hur G.M.
    Kim J.-L.
    Cho J.Y.
    Seok J.H.
    Park J.
    Toxicological Research, 2008, 24 (3) : 175 - 182
  • [40] DNA-dependent protein kinase inhibition radiosensitizes human cervical cancer cell lines
    Zempolich, Karen
    Clark, Erin
    Fuhrman, Christa
    Lacoursiere, D. Yvette
    Soisson, Andrew P.
    Gaffney, David K.
    CANCER RESEARCH, 2006, 66 (08)
12345