The DNA-dependent protein kinase: A matter of life and (cell) death

被引：26
|
作者：
McConnell, K
Dynan, WS
机构：
[1] Medical College of Georgia, Inst. for Molec. Med. and Genetics, Augusta, GA 30912-3175
来源：
CURRENT OPINION IN CELL BIOLOGY | 1996年 / 8卷 / 03期
关键词：
D O I：
10.1016/S0955-0674(96)80005-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The catalytic subunit of the DNA-dependent protein kinase (DNA-PK) is a member of the phosphatidylinositol 3-kinase family. Recent genetic and biochemical studies indicate the involvement of DNA-PK in immunoglobulin/T-celI-receptor gene recombination, double-strand DNA break repair, the stress response and autoimmunity. A role in the suppression of apoptosis could link some of the enzyme's diverse functions.
引用
收藏
页码：325 / 330
页数：6
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