LABEL-FREE DETECTION OF CORDYCEPS SINENSIS BY DUAL-GATE NANORIBBON-BASED ION-SENSITIVE FIELD-EFFECT TRANSISTOR BIOSENSOR

被引：0
|
作者：
Ma, Shenhui [1 ,2 ]
Luo, Tianqi [1 ]
Wei, Guang [1 ]
Gao, Bo [3 ]
Lee, Yi-Kuen [2 ,3 ]
Zhang, Anping [1 ]
机构：
[1] Xi An Jiao Tong Univ, State Key Lab Elect Insulat & Power Equipment, Xian, Shaanxi, Peoples R China
[2] HKUST, Dept Mech & Aerosp Engn, Hong Kong, Hong Kong, Peoples R China
[3] HKUST, Div Biomed Engn, Hong Kong, Hong Kong, Peoples R China
来源：
2017 19TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS (TRANSDUCERS) | 2017年
关键词：
Dual-gate ISFET; conductance measurements; DNA detection; Cordyceps sinensis; FABRICATION; DNA;
D O I：
暂无
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
We report a dual-gate nanoribbon-based Ion-sensitive field-effect transistor (NR-ISFET) biosensor system for detection of Cordyceps sinensis's DNA (CorDNA). Direct label-free detection of the CorDNA is achieved by conductance measurements of the NR-ISFET biosensors with both Au and SiO2 as sensing layers. Compared with previous methods for CorDNA detection, the NR-ISFET biosensor demonstrates smaller sample volume, lower detection concentration and shorter response time. Especially in dual-gate (DG) mode it exhibits a better sensitivity of 0.3090 mS/dec in a wide concentration range spanning four orders of magnitude, a lower limit of detection (LOD) of 100 pM, and significantly improved specificity as compared to single solution-gate (SG) mode.
引用
收藏
页码：646 / 649
页数：4
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