LABEL-FREE DETECTION OF CORDYCEPS SINENSIS BY DUAL-GATE NANORIBBON-BASED ION-SENSITIVE FIELD-EFFECT TRANSISTOR BIOSENSOR

被引：0

作者：

Ma, Shenhui ^{[1
,2
]}

Luo, Tianqi ^{[1
]}

Wei, Guang ^{[1
]}

Gao, Bo ^{[3
]}

Lee, Yi-Kuen ^{[2
,3
]}

Zhang, Anping ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, State Key Lab Elect Insulat & Power Equipment, Xian, Shaanxi, Peoples R China

[2] HKUST, Dept Mech & Aerosp Engn, Hong Kong, Hong Kong, Peoples R China

[3] HKUST, Div Biomed Engn, Hong Kong, Hong Kong, Peoples R China

来源：

2017 19TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS (TRANSDUCERS) | 2017年

关键词：

Dual-gate ISFET; conductance measurements; DNA detection; Cordyceps sinensis; FABRICATION; DNA;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

We report a dual-gate nanoribbon-based Ion-sensitive field-effect transistor (NR-ISFET) biosensor system for detection of Cordyceps sinensis's DNA (CorDNA). Direct label-free detection of the CorDNA is achieved by conductance measurements of the NR-ISFET biosensors with both Au and SiO2 as sensing layers. Compared with previous methods for CorDNA detection, the NR-ISFET biosensor demonstrates smaller sample volume, lower detection concentration and shorter response time. Especially in dual-gate (DG) mode it exhibits a better sensitivity of 0.3090 mS/dec in a wide concentration range spanning four orders of magnitude, a lower limit of detection (LOD) of 100 pM, and significantly improved specificity as compared to single solution-gate (SG) mode.

引用

页码：646 / 649

页数：4

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