In vitro cytotoxicity of monodispersed hematite nanoparticles on Hek 293 cells

被引：26
|
作者：
Yan, Haijuan [1 ,2 ]
Zhang, Benshu [1 ]
机构：
[1] Tianjin Med Univ, Tianjin 300070, Peoples R China
[2] Univ Gottingen, D-37075 Gottingen, Germany
来源：
MATERIALS LETTERS | 2011年 / 65卷 / 05期
关键词：
Hematite nanoparticles; Hydrothermal; Monodispersion; Cytotoxicity; Oxidative stress; SIZE;
D O I：
10.1016/j.matlet.2010.12.004
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
A simple hydrothermal method was developed to prepare monodispersed and well-crystallized hematite nanoparticles with a diameter distribution of about 180 nm. In-vitro cytotoxicity of such nanoparticles was carried out using Hek 293 cell culture system with different dosages. Assessment of cell viability reveals that hematite nanoparticles reduce cell viability in a dose- and time-dependent manner within a rather wide dosage range. Such cytotoxicity is correlative Lathe decrease of the activity of antioxidative enzymes induced by the oxidative stress in cells. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：815 / 817
页数：3
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