An ultrastructural and molecular perspective of the pathological hallmarks of Alzheimer's disease

被引：0
|
作者：
Sobow, T
机构：
[1] SCH MED,DEPT ONCOL,LABS TUMOR BIOL,LAB ELECTRON MICROSCOPY & NEUROPATHOL,LODZ,POLAND
[2] SCH MED,DEPT PSYCHIAT,PSYCHIAT CLIN 2,LODZ,POLAND
来源：
FOLIA NEUROPATHOLOGICA | 1996年 / 34卷 / 01期
关键词：
Alzheimer's disease; neurofibrillary tangles; amyloid plaques;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
An update review of selected issues of the current knowledge of the pathology of Alzheimer's disease, by far the most common cause of human dementia is presented. The molecular basis of the most prominent ultrastructural features of AD including neurofibrillary tangles and the amyloid plaque as well as dystrophic neurites and neuropil threads. The major role of beta APP and its metabolic pathways in the pathogenesis of AD has been strongly pointed out.
引用
收藏
页码：55 / 62
页数：8
相关论文
共 50 条
  • [41] Pathological phenotypes of astrocytes in Alzheimer’s disease
    Junhyung Kim
    Ik Dong Yoo
    Jaejoon Lim
    Jong-Seok Moon
    Experimental & Molecular Medicine, 2024, 56 : 95 - 99
  • [42] Pathological determinants of dementia in Alzheimer's disease
    Royall, DR
    Mulroy, A
    Polk, MJ
    ANNALS OF NEUROLOGY, 1999, 46 (03) : 451 - 451
  • [43] Cholesterol and pathological processes in Alzheimer's disease
    Yanagisawa, K
    JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 70 (03) : 361 - 366
  • [44] Pathological phenotypes of astrocytes in Alzheimer's disease
    Kim, Junhyung
    Yoo, Ik Dong
    Lim, Jaejoon
    Moon, Jong-Seok
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2024, 56 (01): : 95 - 99
  • [45] Targeting Pathological Proteins in Alzheimer's Disease
    Herline, Krystal
    Goni, Fernando
    Wisniewski, Thomas
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2017, 76 (06): : 503 - 504
  • [46] The pathological role of cholesterol in Alzheimer's disease
    Roher, AE
    CELLULAR AND MOLECULAR NEUROBIOLOGY, 2003, 23 (02) : 227 - 227
  • [47] Pathological role of hypoxia in Alzheimer's disease
    Zhang, Xin
    Le, Weidong
    EXPERIMENTAL NEUROLOGY, 2010, 223 (02) : 299 - 303
  • [48] Sleep-wake regulation and the hallmarks of the pathogenesis of Alzheimer's disease
    Van Egroo, Maxime
    Narbutas, Justinas
    Chylinski, Daphne
    Gonzalez, Pamela Villar
    Maquet, Pierre
    Salmon, Eric
    Bastin, Christine
    Collette, Fabienne
    Vandewalle, Gilles
    SLEEP, 2019, 42 (04)
  • [49] Capturing the Alzheimer's disease pathological cascade
    Tijms, Betty M.
    Visser, Pieter Jelle
    LANCET NEUROLOGY, 2018, 17 (03): : 199 - 200
  • [50] Pathological Nuclear Hallmarks in Dentate Granule Cells of Alzheimer's Patients: A Biphasic Regulation of Neurogenesis
    Gil, Laura
    Chi-Ahumada, Erika
    Nino, Sandra A.
    Capdeville, Gabriela
    Mendez-Torres, Areli M.
    Guerrero, Carmen
    Rebolledo, Ana B.
    Olazabal, Isabel M.
    Jimenez-Capdeville, Maria E.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (21)
12345