An ultrastructural and molecular perspective of the pathological hallmarks of Alzheimer's disease

被引：0
|
作者：
Sobow, T
机构：
[1] SCH MED,DEPT ONCOL,LABS TUMOR BIOL,LAB ELECTRON MICROSCOPY & NEUROPATHOL,LODZ,POLAND
[2] SCH MED,DEPT PSYCHIAT,PSYCHIAT CLIN 2,LODZ,POLAND
来源：
FOLIA NEUROPATHOLOGICA | 1996年 / 34卷 / 01期
关键词：
Alzheimer's disease; neurofibrillary tangles; amyloid plaques;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
An update review of selected issues of the current knowledge of the pathology of Alzheimer's disease, by far the most common cause of human dementia is presented. The molecular basis of the most prominent ultrastructural features of AD including neurofibrillary tangles and the amyloid plaque as well as dystrophic neurites and neuropil threads. The major role of beta APP and its metabolic pathways in the pathogenesis of AD has been strongly pointed out.
引用
收藏
页码：55 / 62
页数：8
相关论文
共 50 条
  • [31] Non-hyperphosphorylated tau accumulates in the pathological hallmarks in presenilin-1 Alzheimer's disease and frontotemporal dementia
    Shepherd, CE
    Schofield, EC
    Gregory, GC
    Halliday, GM
    NEUROBIOLOGY OF AGING, 2004, 25 : S428 - S429
  • [32] Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer's Disease
    Singh, Gourav
    Kumar, Sunil
    Panda, Samir Ranjan
    Kumar, Prabhat
    Rai, Sanskriti
    Verma, Himanshu
    Singh, Yash Pal
    Kumar, Saroj
    Srikrishna, Saripella
    Naidu, V. G. M.
    Modi, Gyan
    ACS CHEMICAL NEUROSCIENCE, 2024, 15 (15): : 2756 - 2778
  • [33] Intrinsic aerobic capacity modulates Alzheimer's disease pathological hallmarks, brain mitochondrial function and proteome during aging
    Kugler, Benjamin A.
    Lysaker, Colton R.
    Franczak, Edziu
    Hauger, Brittany M.
    Csikos, Vivien
    Stopperan, Julia A.
    Allen, Julie A.
    Stanford, John A.
    Koch, Lauren G.
    Britton, Steven L.
    Thyfault, John P.
    Wilkins, Heather M.
    GEROSCIENCE, 2024, : 4955 - 4967
  • [34] In vitro molecular reconstruction of the pathological truncation of tau protein in Alzheimer's disease
    Ovecka, M
    Novak, M
    Cattaneo, A
    CHEMICAL PAPERS, 1998, 52 : 315 - 315
  • [35] Exploring Retinal Neurodegeneration in Alzheimer’s Disease: A Molecular and Cellular Perspective
    Rishika Dhapola
    Prajjwal Sharma
    Sneha Kumari
    Balachandar Vellingiri
    Bikash Medhi
    Dibbanti HariKrishnaReddy
    Neurotoxicity Research, 2025, 43 (2)
  • [36] Transcranial direct current stimulation does not improve memory deficits or alter pathological hallmarks in a rodent model of Alzheimer's disease
    Gondard, Elise
    Luisa Soto-Montenegro, Maria
    Cassol, Amanda
    Lozano, Andres M.
    Hamani, Clement
    JOURNAL OF PSYCHIATRIC RESEARCH, 2019, 114 : 93 - 98
  • [37] Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production
    Heejung Chun
    Hyeonjoo Im
    You Jung Kang
    Yunha Kim
    Jin Hee Shin
    Woojin Won
    Jiwoon Lim
    Yeonha Ju
    Yongmin Mason Park
    Sunpil Kim
    Seung Eun Lee
    Jaekwang Lee
    Junsung Woo
    Yujin Hwang
    Hyesun Cho
    Seonmi Jo
    Jong-Hyun Park
    Daesoo Kim
    Doo Yeon Kim
    Jeong-Sun Seo
    Byoung Joo Gwag
    Young Soo Kim
    Ki Duk Park
    Bong-Kiun Kaang
    Hansang Cho
    Hoon Ryu
    C. Justin Lee
    Nature Neuroscience, 2020, 23 : 1555 - 1566
  • [38] DKK-1 is associated with pathological hallmarks in Alzheimer's disease and other tauopathies and is also seen in head injury.
    Troakes, C.
    Hye, A.
    Jones, S.
    Killick, R.
    Al-Sarraj, S.
    NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2020, 46 : 42 - 42
  • [39] Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H2O2- production
    Chun, Heejung
    Im, Hyeonjoo
    Kang, You Jung
    Kim, Yunha
    Shin, Jin Hee
    Won, Woojin
    Lim, Jiwoon
    Ju, Yeonha
    Park, Yongmin Mason
    Kim, Sunpil
    Lee, Seung Eun
    Lee, Jaekwang
    Woo, Junsung
    Hwang, Yujin
    Cho, Hyesun
    Jo, Seonmi
    Park, Jong-Hyun
    Kim, Daesoo
    Kim, Doo Yeon
    Seo, Jeong-Sun
    Gwag, Byoung Joo
    Kim, Young Soo
    Park, Ki Duk
    Kaang, Bong-Kiun
    Cho, Hansang
    Ryu, Hoon
    Lee, C. Justin
    NATURE NEUROSCIENCE, 2020, 23 (12) : 1555 - U42
  • [40] Pathological stress granules in Alzheimer's disease
    Ash, Peter E. A.
    Vanderweyde, Tara E.
    Youmans, Katherine L.
    Apicco, Daniel J.
    Wolozin, Benjamin
    BRAIN RESEARCH, 2014, 1584 : 52 - 58
12345