T cell receptors get back to basics

被引：3

作者：

Jones, E. Yvonne ^{[1
]}

Salio, Mariolina

Cerundolo, Vincenzo

机构：

[1] Henry Wellcome Bldg Genomic Med, Canc Res UK Receptor Struct Res Grp, Oxford OX3 7BN, England

[2] Univ Oxford, Weather Inst Mol Med, Nuffield Dept Med, Canc Res UK Tumor Immunol Grp, Oxford OX3 9DS, England

来源：

NATURE IMMUNOLOGY | 2007年 / 8卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/ni1007-1033

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

For both mice and humans, an invariant T cell receptor mediates the recognition of glycolipid antigens presented in the context of CD1d molecules. Crystal structure and mutagenesis-based analyses now identify a minimalist binding mode well suited to an 'innate-style' pattern-recognition function.

引用

页码：1033 / 1035

页数：3

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