T cell receptors get back to basics

被引:3
|
作者
Jones, E. Yvonne [1 ]
Salio, Mariolina
Cerundolo, Vincenzo
机构
[1] Henry Wellcome Bldg Genomic Med, Canc Res UK Receptor Struct Res Grp, Oxford OX3 7BN, England
[2] Univ Oxford, Weather Inst Mol Med, Nuffield Dept Med, Canc Res UK Tumor Immunol Grp, Oxford OX3 9DS, England
基金
英国医学研究理事会;
关键词
D O I
10.1038/ni1007-1033
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
For both mice and humans, an invariant T cell receptor mediates the recognition of glycolipid antigens presented in the context of CD1d molecules. Crystal structure and mutagenesis-based analyses now identify a minimalist binding mode well suited to an 'innate-style' pattern-recognition function.
引用
收藏
页码:1033 / 1035
页数:3
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