机构:
Henry Wellcome Bldg Genomic Med, Canc Res UK Receptor Struct Res Grp, Oxford OX3 7BN, EnglandHenry Wellcome Bldg Genomic Med, Canc Res UK Receptor Struct Res Grp, Oxford OX3 7BN, England
Jones, E. Yvonne
[1
]
Salio, Mariolina
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机构:Henry Wellcome Bldg Genomic Med, Canc Res UK Receptor Struct Res Grp, Oxford OX3 7BN, England
Salio, Mariolina
Cerundolo, Vincenzo
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机构:Henry Wellcome Bldg Genomic Med, Canc Res UK Receptor Struct Res Grp, Oxford OX3 7BN, England
Cerundolo, Vincenzo
机构:
[1] Henry Wellcome Bldg Genomic Med, Canc Res UK Receptor Struct Res Grp, Oxford OX3 7BN, England
[2] Univ Oxford, Weather Inst Mol Med, Nuffield Dept Med, Canc Res UK Tumor Immunol Grp, Oxford OX3 9DS, England
For both mice and humans, an invariant T cell receptor mediates the recognition of glycolipid antigens presented in the context of CD1d molecules. Crystal structure and mutagenesis-based analyses now identify a minimalist binding mode well suited to an 'innate-style' pattern-recognition function.