Novel Schiff base scaffolds derived from 4-aminoantipyrine and 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde: Synthesis, antibacterial, antioxidant and anti-inflammatory

被引：4
|
作者：
Kasare, Mangesh S. [1 ]
Dhavan, Pratik P. [2 ]
Shaikh, Aksh Hina, I [1 ]
Jadhav, Bhaskar L. [2 ]
Pawar, Suresh D. [1 ]
机构：
[1] Univ Mumbai, Dept Chem, Mumbai 400098, Maharashtra, India
[2] Univ Mumbai, Dept Life Sci, Mumbai, Maharashtra, India
来源：
JOURNAL OF MOLECULAR RECOGNITION | 2022年 / 35卷 / 09期
关键词：
4-aminoantipyrine; antibacterial; anti-inflammatory; antioxidant; azo-Schiff base; SPECTRAL CHARACTERIZATION; ANTIMICROBIAL ACTIVITIES; METAL(II) COMPLEXES; COPPER-COMPLEXES; LIGANDS; ACID;
D O I：
10.1002/jmr.2976
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of four new azo-Schiff base ligands from 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde and 4-aminoantipyrine is described in this study. The molecular structures of all the scaffolds were confirmed using NMR spectroscopies such as H-1 and C-13, as well as FT-IR and Mass spectroscopy. After successful synthesis and characterization of all the ligands, their in vitro antibacterial, antioxidant and anti-inflammatory activities were carried out by using standard protocols. Results revealed that all the four ligands (L1-L4) possessed excellent biological potency.
引用
收藏
页数：7
相关论文
共 50 条
  • [21] Synthesis of novel 2, 3, 5-tri-substituted thiazoles with anti-inflammatory and antibacterial effect causing clinical pathogens
    Ahmed, Aejaz
    Molvi, Khurshid, I
    Patel, Harun M.
    Ullah, Riaz
    Bari, Ahmed
    JOURNAL OF INFECTION AND PUBLIC HEALTH, 2020, 13 (04) : 472 - 479
  • [22] Synthesis, characterization and biological evaluation of novel 4′-fluoro-2′-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents
    Abdellatif, Khaled R. A.
    Elshemy, Heba A. H.
    Salama, Samir A.
    Omar, Hany A.
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2015, 30 (03) : 484 - 491
  • [23] Novel 4,5-diaryl-3-hydroxy-2(5H)-furanones as anti-oxidants and anti-inflammatory agents
    Weber, V
    Coudert, P
    Rubat, C
    Duroux, E
    Vallée-Goyet, D
    Gardette, D
    Bria, M
    Albuisson, E
    Leal, F
    Gramain, JC
    Couquelet, J
    Madesclaire, M
    BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (06) : 1647 - 1658
  • [24] Synthesis, characterization and biological activity of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes derived from Schiff base ligand quinoxaline-2-carboxaldehyde and 4-aminoantipyrine
    Alyaninezhad, Zohreh
    Bekhradnia, Ahmadreza
    Gorgi, Reza Zibandeh
    Ghanbarimasir, Zahra
    Fouladpour, Morteza
    JOURNAL OF MOLECULAR STRUCTURE, 2022, 1262
  • [25] Novel Schiff base derivatives containing 4,5-disubstituted thiazole as potential antibiofilm, anti-inflammatory and antioxidant agents: Green synthesis, molecular docking and ADME analysis
    Bhosale, Dnyandev
    Narale, Ashwini
    Hadimani, Pushpa
    Kokane, Megha
    Mali, Mukund
    Shringare, Sadanand
    Raut, Dattatraya
    Bamankar, Mukta
    Kathwate, Gunderao
    Damale, Manoj
    Lawand, Anjana
    JOURNAL OF MOLECULAR STRUCTURE, 2024, 1311
  • [26] SYNTHESIS, CHARACTERISATION AND ANTIBACTERIAL ACTIVITY OF BENZOHYDRAZONES DERIVED FROM 3-HYDROXY-5-HYDROXYMETHYL-2-METHYLPYRIDINE-4-CARBOXALDEHYDE
    Ramdas, Kavitha
    Sireesha, B.
    Reddy, Ch Venkata Ramana
    HETEROCYCLIC LETTERS, 2016, 6 (04): : 741 - 747
  • [27] Synthesis, anti-inflammatory activity, and QSAR study of some Schiff bases derived from 5-mercapto-3-(4'-pyridyl)-4H-1,2,4-triazol-4-yl-thiosemicarbazide
    Sachdeva, Harshita
    Dwivedi, Diksha
    Arya, Kapil
    Khaturia, Sarita
    Saroj, Rekha
    MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (10) : 4953 - 4963
  • [28] Synthesis, anti-inflammatory activity, and QSAR study of some Schiff bases derived from 5-mercapto-3-(4′-pyridyl)-4H-1,2,4-triazol-4-yl-thiosemicarbazide
    Harshita Sachdeva
    Diksha Dwivedi
    Kapil Arya
    Sarita Khaturia
    Rekha Saroj
    Medicinal Chemistry Research, 2013, 22 : 4953 - 4963
  • [29] Synthesis, characterization and anticancer studies of Ni(II), Pd(II) and Pt(II) complexes with Schiff base derived from N-methylhydrazinecarbothioamide and 2-hydroxy-5-methoxy-3-nitrobenzaldehyde
    Arafath, Md. Azharul
    Adam, Farook
    Razali, Mohd. R.
    Hassan, Loiy E. Ahmed
    Ahamed, Mohamed B. Khadeer
    Majid, Amin Malik S. A.
    JOURNAL OF MOLECULAR STRUCTURE, 2017, 1130 : 791 - 798
  • [30] Design, synthesis, and pharmacological evaluation of some 2-[4-morpholinol-3-aryl-5-substituted thiophenes as novel anti-inflammatory agents: generation of a novel anti-inflammatory pharmacophore
    Pillai, AD
    Rathod, PD
    Xavier, FP
    Vasu, KK
    Padh, H
    Sudarsanam, V
    BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (17) : 4667 - 4671
12345