Novel Schiff base scaffolds derived from 4-aminoantipyrine and 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde: Synthesis, antibacterial, antioxidant and anti-inflammatory

被引：4
|
作者：
Kasare, Mangesh S. [1 ]
Dhavan, Pratik P. [2 ]
Shaikh, Aksh Hina, I [1 ]
Jadhav, Bhaskar L. [2 ]
Pawar, Suresh D. [1 ]
机构：
[1] Univ Mumbai, Dept Chem, Mumbai 400098, Maharashtra, India
[2] Univ Mumbai, Dept Life Sci, Mumbai, Maharashtra, India
来源：
JOURNAL OF MOLECULAR RECOGNITION | 2022年 / 35卷 / 09期
关键词：
4-aminoantipyrine; antibacterial; anti-inflammatory; antioxidant; azo-Schiff base; SPECTRAL CHARACTERIZATION; ANTIMICROBIAL ACTIVITIES; METAL(II) COMPLEXES; COPPER-COMPLEXES; LIGANDS; ACID;
D O I：
10.1002/jmr.2976
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of four new azo-Schiff base ligands from 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde and 4-aminoantipyrine is described in this study. The molecular structures of all the scaffolds were confirmed using NMR spectroscopies such as H-1 and C-13, as well as FT-IR and Mass spectroscopy. After successful synthesis and characterization of all the ligands, their in vitro antibacterial, antioxidant and anti-inflammatory activities were carried out by using standard protocols. Results revealed that all the four ligands (L1-L4) possessed excellent biological potency.
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页数：7
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