Novel Schiff base scaffolds derived from 4-aminoantipyrine and 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde: Synthesis, antibacterial, antioxidant and anti-inflammatory

被引：4
|
作者：
Kasare, Mangesh S. [1 ]
Dhavan, Pratik P. [2 ]
Shaikh, Aksh Hina, I [1 ]
Jadhav, Bhaskar L. [2 ]
Pawar, Suresh D. [1 ]
机构：
[1] Univ Mumbai, Dept Chem, Mumbai 400098, Maharashtra, India
[2] Univ Mumbai, Dept Life Sci, Mumbai, Maharashtra, India
来源：
JOURNAL OF MOLECULAR RECOGNITION | 2022年 / 35卷 / 09期
关键词：
4-aminoantipyrine; antibacterial; anti-inflammatory; antioxidant; azo-Schiff base; SPECTRAL CHARACTERIZATION; ANTIMICROBIAL ACTIVITIES; METAL(II) COMPLEXES; COPPER-COMPLEXES; LIGANDS; ACID;
D O I：
10.1002/jmr.2976
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of four new azo-Schiff base ligands from 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde and 4-aminoantipyrine is described in this study. The molecular structures of all the scaffolds were confirmed using NMR spectroscopies such as H-1 and C-13, as well as FT-IR and Mass spectroscopy. After successful synthesis and characterization of all the ligands, their in vitro antibacterial, antioxidant and anti-inflammatory activities were carried out by using standard protocols. Results revealed that all the four ligands (L1-L4) possessed excellent biological potency.
引用
收藏
页数：7
相关论文
共 50 条
  • [1] Synthesis, Characterization Study of Schiff base Complexes derived from Ampicillin and 4-Hydroxy-3-methoxy benzaldehyde
    Subitha, S.
    Kanmoni, V. Gnana Glory
    Raj, C. Isac Sobana
    Jona, J.
    Vibi, V.
    ORIENTAL JOURNAL OF CHEMISTRY, 2021, 37 (04) : 813 - 818
  • [2] Synthesis, characterization, crystal structure, in silico and computational studies on a novel Schiff base derived from α-chlorocinnamaldehyde and 4-aminoantipyrine
    Adimudo, Hillary Chijioke
    Agu, Chidike Justus
    Okenyeka, Obinna U.
    Eddy, Nnabuk O.
    Dim, Ebubechukwu Nnamdi
    Dege, Necmi
    Bonardd, Sebastian
    Vanka, Kumar
    Ibezim, Akachukwu
    Idika, Digbo Iku
    Diaz, David Diaz
    Obasi, Nnamdi Lawrence
    JOURNAL OF MOLECULAR STRUCTURE, 2023, 1289
  • [3] Synthesis and characterization of metal complexes of Schiff base ligand derived from imidazole-2-carboxaldehyde and 4-aminoantipyrine
    Joseyphus, R. Selwin
    Shiju, C.
    Joseph, J.
    Dhanaraj, C. Justin
    Arish, D.
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2014, 133 : 149 - 155
  • [4] STUDIES OF DIOXOURANIUM(VI) COMPLEXES OF A SCHIFF-BASE DERIVED FROM BENZOCAIN AND 4-HYDROXY-3-METHOXY-BENZALDEHYDE
    AGARWAL, RK
    ARORA, K
    DUTT, P
    NATIONAL ACADEMY SCIENCE LETTERS-INDIA, 1992, 15 (09): : 295 - 298
  • [5] Synthesis, characterization, antioxidant activities and DFT calculations of 2,4-bis (2-hydroxy-3-methoxy benzaldehyde) diiminotoluene Schiff base
    Abdallah, Ameera Abd Almajeed Madi
    Haffar, Djahida
    Benghanem, Fatiha
    Ghedjati, Samira
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2023, 20 (04) : 897 - 910
  • [6] Synthesis, characterization, antioxidant activities and DFT calculations of 2,4-bis (2-hydroxy-3-methoxy benzaldehyde) diiminotoluene Schiff base
    Ameera Abd Almajeed Madi Abdallah
    Djahida Haffar
    Fatiha Benghanem
    Samira Ghedjati
    Journal of the Iranian Chemical Society, 2023, 20 : 897 - 910
  • [7] SYNTHESIS AND SPECTROSCOPIC STUDIES OF LANTHANIDE(III) PERCHLORATES COMPLEXES WITH SCHIFF-BASES DERIVED FROM 4-METHOXYBENZALDEHYDE-4-HYDROXY-3-METHOXYBENZALDEHYDE AND 4-AMINOANTIPYRINE
    AGARWAL, RK
    SARIN, RK
    POLISH JOURNAL OF CHEMISTRY, 1993, 67 (11) : 1925 - 1931
  • [8] Synthesis, spectral characterization, redox and antimicrobial activity of Schiff base transition metal(II) complexes derived from 4-aminoantipyrine and 3-salicylideneacetylacetone
    Raman, N
    Thangaraja, C
    Johnsonraja, S
    CENTRAL EUROPEAN JOURNAL OF CHEMISTRY, 2005, 3 (03): : 537 - 555
  • [9] Synthesis, Spectral and Quantum-Chemical Calculations on 5-Bromo-4-hydroxy-3-methoxy-2-nitro Benzaldehyde Schiff Base of S-Benzyldithiocarbazate
    Singh, Rajeev
    Kumar, D.
    Goswami, Y. C.
    Sharma, Ranjana
    ASIAN JOURNAL OF CHEMISTRY, 2012, 24 (12) : 5522 - 5524
  • [10] Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity
    Alam, Mohammad Sayed
    Choi, Jung-Hyun
    Lee, Dong-Ung
    BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (13) : 4103 - 4108
12345