HIV-1 Virological Synapse: Live Imaging of Transmission

被引：35

作者：

Feldmann, Jerome ^{[1
]}

Schwartz, Olivier ^{[1
]}

机构：

[1] Inst Pasteur, Virus & Immun Unit, URA CNRS 3015, F-75724 Paris, France

来源：

VIRUSES-BASEL | 2010年 / 2卷 / 08期

关键词：

HIV-1; virological synapse; live video-microscopy; HUMAN-IMMUNODEFICIENCY-VIRUS; TO-CELL TRANSMISSION; PLASMA-MEMBRANE; IMMUNOLOGICAL SYNAPSES; ENVELOPE GLYCOPROTEIN; PERIPHERAL-BLOOD; MULTIPLE TARGETS; SORTING SIGNAL; EARLY EVENTS; HIGH-LEVEL;

D O I：

10.3390/v2081666

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell imaging. Together with the accumulated knowledge on cellular and molecular structures involved in cell-to-cell transmission of HIV-1, the visualization of the virological synapse in video-microscopy has brought exciting new hypotheses on its underlying mechanisms. This review will recapitulate current knowledge with a particular emphasis on the questions live microscopy has raised.

引用

页码：1666 / 1680

页数：15

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