HIV-1 Virological Synapse: Live Imaging of Transmission

被引：35
|
作者：
Feldmann, Jerome [1 ]
Schwartz, Olivier [1 ]
机构：
[1] Inst Pasteur, Virus & Immun Unit, URA CNRS 3015, F-75724 Paris, France
来源：
VIRUSES-BASEL | 2010年 / 2卷 / 08期
关键词：
HIV-1; virological synapse; live video-microscopy; HUMAN-IMMUNODEFICIENCY-VIRUS; TO-CELL TRANSMISSION; PLASMA-MEMBRANE; IMMUNOLOGICAL SYNAPSES; ENVELOPE GLYCOPROTEIN; PERIPHERAL-BLOOD; MULTIPLE TARGETS; SORTING SIGNAL; EARLY EVENTS; HIGH-LEVEL;
D O I：
10.3390/v2081666
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell imaging. Together with the accumulated knowledge on cellular and molecular structures involved in cell-to-cell transmission of HIV-1, the visualization of the virological synapse in video-microscopy has brought exciting new hypotheses on its underlying mechanisms. This review will recapitulate current knowledge with a particular emphasis on the questions live microscopy has raised.
引用
收藏
页码：1666 / 1680
页数：15
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