Self-Assembled DNA Hydrogels with Designable Thermal and Enzymatic Responsiveness

被引：370
|
作者：
Xing, Yongzheng [1 ,2 ]
Cheng, Enjun [2 ]
Yang, Yang [2 ]
Chen, Ping [3 ]
Zhang, Tao [3 ]
Sun, Yawei [2 ]
Yang, Zhongqiang [1 ]
Liu, Dongsheng [1 ]
机构：
[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China
[2] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
[3] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China
来源：
ADVANCED MATERIALS | 2011年 / 23卷 / 09期
关键词：
PROTEIN; NANOPARTICLES; APTAMER; RELEASE;
D O I：
10.1002/adma.201003343
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An easy and versatile approach to construct DNA hydrogels is reported. The DNA building blocks, a Y-scaffold and a linker, can self-assemble into DNA hydrogels by the hybridization of their "sticky ends". It is shown that the DNA hydrogels undergo a sol-gel transition upon heat or enzymatic treatment, and the responsiveness can be adjusted by tailoring the sequence of the building blocks.
引用
收藏
页码：1117 / 1121
页数：5
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