Self-Assembled DNA Hydrogels with Designable Thermal and Enzymatic Responsiveness

被引：370

作者：

Xing, Yongzheng ^{[1
,2
]}

Cheng, Enjun ^{[2
]}

Yang, Yang ^{[2
]}

Chen, Ping ^{[3
]}

Zhang, Tao ^{[3
]}

Sun, Yawei ^{[2
]}

Yang, Zhongqiang ^{[1
]}

Liu, Dongsheng ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China

[2] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

[3] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 09期

关键词：

PROTEIN; NANOPARTICLES; APTAMER; RELEASE;

D O I：

10.1002/adma.201003343

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An easy and versatile approach to construct DNA hydrogels is reported. The DNA building blocks, a Y-scaffold and a linker, can self-assemble into DNA hydrogels by the hybridization of their "sticky ends". It is shown that the DNA hydrogels undergo a sol-gel transition upon heat or enzymatic treatment, and the responsiveness can be adjusted by tailoring the sequence of the building blocks.

引用

页码：1117 / 1121

页数：5

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