Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells

被引：309
|
作者：
Goel, A [1 ]
Boland, CR [1 ]
Chauhan, DP [1 ]
机构：
[1] Univ Calif San Diego, Dept Med, Div Gastroenterol, La Jolla, CA 92093 USA
来源：
CANCER LETTERS | 2001年 / 172卷 / 02期
关键词：
curcumin; chemoprevention; colon cancer; cyclooxygenase-1; cyclooxygenase-2;
D O I：
10.1016/S0304-3835(01)00655-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory and anticancer activities. Cyclooxygenase (COX)-2 plays an important role in colon carcinogenesis. To investigate the effect of curcumin on COX-2 expression, we treated HT-29 human colon cancer cells with various concentrations of curcumin. Curcumin inhibited the cell growth of HT-29 cells in a concentration- and time-dependent manner. Curcumin markedly inhibited the mRNA and protein expression of COX-2, but not COX-1. These data suggest that a non-toxic concentration of curcumin has a significant effect on the in vitro growth of HT-29 cells, specifically inhibits COX-2 expression, and may have value as a safe chemopreventive agent for colon cancer. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：111 / 118
页数：8
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