Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells

被引：309
|
作者：
Goel, A [1 ]
Boland, CR [1 ]
Chauhan, DP [1 ]
机构：
[1] Univ Calif San Diego, Dept Med, Div Gastroenterol, La Jolla, CA 92093 USA
来源：
CANCER LETTERS | 2001年 / 172卷 / 02期
关键词：
curcumin; chemoprevention; colon cancer; cyclooxygenase-1; cyclooxygenase-2;
D O I：
10.1016/S0304-3835(01)00655-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory and anticancer activities. Cyclooxygenase (COX)-2 plays an important role in colon carcinogenesis. To investigate the effect of curcumin on COX-2 expression, we treated HT-29 human colon cancer cells with various concentrations of curcumin. Curcumin inhibited the cell growth of HT-29 cells in a concentration- and time-dependent manner. Curcumin markedly inhibited the mRNA and protein expression of COX-2, but not COX-1. These data suggest that a non-toxic concentration of curcumin has a significant effect on the in vitro growth of HT-29 cells, specifically inhibits COX-2 expression, and may have value as a safe chemopreventive agent for colon cancer. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：111 / 118
页数：8
相关论文
共 50 条
  • [31] Cyclooxygenase-2 (Cox-2) expression and angiogenesis in glioblastoma
    Onguru, Onder
    Gamsizkan, Mehmet
    Ulutin, Cuneyt
    Gunhan, Omer
    NEUROPATHOLOGY, 2008, 28 (01) : 29 - 34
  • [32] Expression of cyclooxygenase-2 (COX-2) in pituitary tumours
    Sokolowski, Grzegorz
    Baldys-Waligorska, Agata
    Trofimiuk, Malgorzata
    Adamek, Dariusz
    Hubalewska-Dydejczyk, Alicja
    Golkowski, Filip
    MEDICAL SCIENCE MONITOR, 2012, 18 (04): : CR252 - CR259
  • [33] Cyclooxygenase-2 (Cox-2) expression and angiogenesis in glioblastoma
    Onguru, Onder
    Gamsizkan, Mehmet
    Ulutin, Cuneyt
    Gunhan, Omer
    VIRCHOWS ARCHIV, 2007, 451 (02) : 238 - 238
  • [34] Cyclooxygenase-2 (COX-2) siRNA inhibits the expression of COX-2 protein and the growth of human hepatocellular carcinoma cells.
    Park, JW
    Park, JE
    Lee, JA
    Lee, CW
    Kim, CM
    HEPATOLOGY, 2004, 40 (04) : 373A - 373A
  • [35] Similar reductions in the risk of human colon cancer by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors
    Randall E Harris
    Joanne Beebe-Donk
    Galal A Alshafie
    BMC Cancer, 8
  • [36] Similar reductions in the risk of human colon cancer by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors
    Harris, Randall E.
    Beebe-Donk, Joanne
    Alshafie, Galal A.
    BMC CANCER, 2008, 8 (1)
  • [37] Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells
    Maier, TJ
    Schilling, K
    Schmidt, R
    Geisslinger, G
    Grösch, S
    BIOCHEMICAL PHARMACOLOGY, 2004, 67 (08) : 1469 - 1478
  • [38] Expression of cyclooxygenase 2 (COX-2) in human glioma and in Vitro inhibition by a specific COX-2 inhibitor, NS-398
    Joki, T
    Heese, O
    Nikas, DC
    Bello, L
    Zhang, JP
    Kraeft, SK
    Seyfried, NT
    Abe, T
    Chen, LB
    Carroll, RS
    Black, PM
    CANCER RESEARCH, 2000, 60 (17) : 4926 - 4931
  • [39] Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway
    Ha, Jun
    Zhao, Li
    Zhao, Qing
    Yao, Jing
    Zhu, Bin-Bin
    Lu, Na
    Ke, Xue
    Yang, Hui-Ying
    Li, Zhiyu
    You, Qi-Dong
    Guo, Qing-Long
    BIOCHEMISTRY AND CELL BIOLOGY, 2012, 90 (04) : 521 - 531
  • [40] Differences in the ability of α-tocopherol and γ-tocopherol to suppress deoxycholic acid (DCA)-induced suppression of cyclooxygenase-2 (COX-2) protein in HCT-116 and HT-29 human colon cancer cell lines.
    Campbell, S
    McHaffie, D
    Whaley, S
    Stone, W
    Krishnan, K
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2003, 12 (11) : 1296S - 1296S
12345