Quantitative assessment of TIM-3 polymorphisms and cancer risk in Chinese Han population

被引：13
|
作者：
Gao, Xueren [1 ]
Yang, Jiaojiao [1 ]
He, Youji [1 ]
Zhang, Jianqiong [1 ,2 ,3 ]
机构：
[1] Southeast Univ, Sch Med, Dept Microbiol & Immunol, Nanjing, Jiangsu, Peoples R China
[2] Southeast Univ, Sch Med, Jiangsu Key Lab Mol Imaging & Funct Imaging, Nanjing, Jiangsu, Peoples R China
[3] Southeast Univ, Sch Med, Minist Educ, Key Lab Dev Genes & Human Dis, Nanjing, Jiangsu, Peoples R China
来源：
ONCOTARGET | 2016年 / 7卷 / 24期
基金：
中国国家自然科学基金;
关键词：
TIM-3; polymorphism; cancer; 3 GENE POLYMORPHISMS; CHRONIC HEPATITIS-B; CELL CARCINOMA; MOLECULE; INFECTION; DISEASE; SUSCEPTIBILITY;
D O I：
10.18632/oncotarget.8157
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Previous studies have investigated the associations of TIM-3 polymorphisms (-1516G/T, -574G/T, and +4259T/G) with cancer risk in Chinese Han population, but the results remain conflicting. Therefore, we conducted a meta-analysis to derive a more precise estimation of the associations. The pooled data showed that TIM-3 polymorphisms (-1516G/T, -574G/T, and +4259T/G) were significantly associated with an increased risk of overall cancer in Chinese Han population. Subgroup analyses based on cancer system showed that TIM-3 -1516G/T polymorphism was only associated with an increased risk of digestive system cancer in Chinese Han population. TIM-3 -574G/T polymorphism was associated with an increased risk of digestive system cancer and other cancer in Chinese Han population. TIM-3 +4259T/G polymorphism was only associated with an increased risk of other cancer in Chinese Han population. In summary, our results indicated that TIM-3 polymorphisms (-1516G/T, -574G/T, and +4259T/G) were associated with the increased risk of cancer in Chinese Han population.
引用
收藏
页码：35768 / 35775
页数：8
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