Quantitative assessment of TIM-3 polymorphisms and cancer risk in Chinese Han population

被引：13

作者：

Gao, Xueren ^{[1
]}

Yang, Jiaojiao ^{[1
]}

He, Youji ^{[1
]}

Zhang, Jianqiong ^{[1
,2
,3
]}

机构：

[1] Southeast Univ, Sch Med, Dept Microbiol & Immunol, Nanjing, Jiangsu, Peoples R China

[2] Southeast Univ, Sch Med, Jiangsu Key Lab Mol Imaging & Funct Imaging, Nanjing, Jiangsu, Peoples R China

[3] Southeast Univ, Sch Med, Minist Educ, Key Lab Dev Genes & Human Dis, Nanjing, Jiangsu, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 24期

基金：

中国国家自然科学基金;

关键词：

TIM-3; polymorphism; cancer; 3 GENE POLYMORPHISMS; CHRONIC HEPATITIS-B; CELL CARCINOMA; MOLECULE; INFECTION; DISEASE; SUSCEPTIBILITY;

D O I：

10.18632/oncotarget.8157

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous studies have investigated the associations of TIM-3 polymorphisms (-1516G/T, -574G/T, and +4259T/G) with cancer risk in Chinese Han population, but the results remain conflicting. Therefore, we conducted a meta-analysis to derive a more precise estimation of the associations. The pooled data showed that TIM-3 polymorphisms (-1516G/T, -574G/T, and +4259T/G) were significantly associated with an increased risk of overall cancer in Chinese Han population. Subgroup analyses based on cancer system showed that TIM-3 -1516G/T polymorphism was only associated with an increased risk of digestive system cancer in Chinese Han population. TIM-3 -574G/T polymorphism was associated with an increased risk of digestive system cancer and other cancer in Chinese Han population. TIM-3 +4259T/G polymorphism was only associated with an increased risk of other cancer in Chinese Han population. In summary, our results indicated that TIM-3 polymorphisms (-1516G/T, -574G/T, and +4259T/G) were associated with the increased risk of cancer in Chinese Han population.

引用

页码：35768 / 35775

页数：8

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