Tyrosinase inhibition studies of diterpenoid alkaloids and their derivatives: structure-activity relationships

被引：7
|
作者：
Sultankhodzhaev, MN
Khan, MTH
Moin, M
Choudhary, MI [1 ]
Atta-Ur-Rahman
机构：
[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan
[2] Uzbek Acad Sci, S Yunusov Inst Chem Plant Subst, Tashkent 700135, Uzbekistan
来源：
NATURAL PRODUCT RESEARCH | 2005年 / 19卷 / 05期
关键词：
diterpenoid alkaloids; Aconitum; Delphinium; tyrosinase inhibitors; vitiligo; lycoctonine; lappaconitine HBr;
D O I：
10.1080/14786410512331330585
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In the present article, tyrosinase inhibition studies on fifteen diterpenoid alkaloids, with lycoctonine skeleton, and their semisynthetic derivatives 1 - 15 and six napelline-type compounds 16 - 21 are discussed. Their structure - activity relationship for tyrosinase inhibition is also discussed. These activities were compared with two referenced tyrosinase inhibitors, kojic acid and L-mimosine. The study showed that lappaconitine HBr ( 1) is the most potent member of the series ( IC50 = 13.30 mu M).
引用
收藏
页码：517 / 522
页数：6
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