Tyrosinase inhibition studies of diterpenoid alkaloids and their derivatives: structure-activity relationships

被引：7

作者：

Sultankhodzhaev, MN

Khan, MTH

Moin, M

Choudhary, MI ^{[1
]}

Atta-Ur-Rahman

机构：

[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

[2] Uzbek Acad Sci, S Yunusov Inst Chem Plant Subst, Tashkent 700135, Uzbekistan

来源：

NATURAL PRODUCT RESEARCH | 2005年 / 19卷 / 05期

关键词：

diterpenoid alkaloids; Aconitum; Delphinium; tyrosinase inhibitors; vitiligo; lycoctonine; lappaconitine HBr;

D O I：

10.1080/14786410512331330585

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In the present article, tyrosinase inhibition studies on fifteen diterpenoid alkaloids, with lycoctonine skeleton, and their semisynthetic derivatives 1 - 15 and six napelline-type compounds 16 - 21 are discussed. Their structure - activity relationship for tyrosinase inhibition is also discussed. These activities were compared with two referenced tyrosinase inhibitors, kojic acid and L-mimosine. The study showed that lappaconitine HBr ( 1) is the most potent member of the series ( IC50 = 13.30 mu M).

引用

页码：517 / 522

页数：6

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