Natural products analogs as scaffolds for supramolecular and combinatorial chemistry

被引：73
|
作者：
Mink, D
Mecozzi, S
Rebek, J [1 ]
机构：
[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 32期
基金：
美国国家卫生研究院; 加拿大自然科学与工程研究理事会;
关键词：
amino acid and derivatives; macrocycles; oxazoles; Combinatorial Chemistry;
D O I：
10.1016/S0040-4039(98)01170-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new class of analogs of natural products useful for supramolecular and combinatorial chemistry is presented. Starting from the structure of natural dolastatins, we have designed and synthesized a series of amino acid-based unnatural rigid platforms having multiple functional groups pointing in the same direction. The stereochemistry of the final product is entirely determined by the chirality of the constituent amino acids. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：5709 / 5712
页数：4
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