Synthesis of macrocyclic scaffolds from natural products and their utilization for solid-phase chemistry

被引：5
|
作者：
Grosche, P
Akyel, KG
Marzinzik, AL [1 ]
机构：
[1] Novartis Inst BioMed Res, Global Discovery Chem, Lead Synth & Chemogenet, CH-4002 Basel, Switzerland
[2] Novartis Inst BioMed Res, Discovery Technol, Analyt & Imaging Sci, CH-4002 Basel, Switzerland
来源：
SYNTHESIS-STUTTGART | 2005年 / 12期
关键词：
combinatorial chemistry; natural products; solid-phase synthesis;
D O I：
10.1055/s-2005-869969
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The versatile synthesis of natural product derived macrocyclic scaffolds suitable for solid- and for solution-phase chemistry is shown. The scaffolds are modified by solid-phase chemistry to yield macrocycles with two points of diversity.
引用
收藏
页码：2015 / 2021
页数：7
相关论文
共 50 条
  • [1] Solid-phase chemistry in the total synthesis of non-peptidic natural products
    Cironi, P
    Alvarez, M
    Albericio, F
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2006, 6 (01) : 11 - 25
  • [2] Solid-phase synthesis of diketopiperazines, useful scaffolds for combinatorial chemistry
    del Fresno, M
    Alsina, J
    Royo, M
    Barany, G
    Albericio, F
    TETRAHEDRON LETTERS, 1998, 39 (17) : 2639 - 2642
  • [3] Pentaerythrityltetramine scaffolds for solid-phase combinatorial chemistry
    Virta, P
    Leppänen, M
    Lönnberg, H
    JOURNAL OF ORGANIC CHEMISTRY, 2004, 69 (06): : 2008 - 2016
  • [4] Solid-phase library synthesis of polyynes similar to natural products
    Lee, Seonwoo
    Lee, Taeho
    Lee, Yun Mi
    Kim, Deukjoon
    Kim, Sanghee
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (44) : 8422 - 8425
  • [5] Highlights in the Solid-Phase Organic Synthesis of Natural Products and Analogues
    Eifler-Lima, Vera Lucia
    Graebin, Cedric S.
    Uchoa, Flavia De Toni
    Duarte, Patricia D.
    Correa, Arlene G.
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2010, 21 (08) : 1401 - 1423
  • [6] Solid-phase approach to the synthesis of cyclen scaffolds from cyclotetrapeptides
    Alcaro, MC
    Orfei, M
    Chelli, M
    Ginanneschi, M
    Papini, AM
    TETRAHEDRON LETTERS, 2003, 44 (28) : 5217 - 5219
  • [7] Cyclative cleavage strategies for the solid-phase synthesis of heterocycles and natural products
    Ganesan, A
    COMBINATORIAL CHEMISTRY, PT B, 2003, 369 : 415 - 434
  • [8] Combinatorial solid-phase natural product chemistry
    Mentel, Matthias
    Breinbauer, Rolf
    COMBINATORIAL CHEMISTRY ON SOLID SUPPORTS, 2007, 278 : 209 - 241
  • [9] Total solid-phase synthesis of Jagaricin, a novel natural macrocyclic lipodepsipeptide from the mushroom pathogen Janthinobacterium agaricidamnosum
    Qin, Chuanguang
    Liu, Huifang
    Lian, Bo
    Shen, Yuanyan
    AMINO ACIDS, 2013, 45 (03) : 610 - 611
  • [10] Solid-phase synthesis of a library of functionalized aminodiol scaffolds
    Davis, PW
    Osgood, SA
    Hébert, N
    Sprankle, KG
    Swayze, EE
    BIOTECHNOLOGY AND BIOENGINEERING, 1998, 61 (03) : 143 - 154
12345